Bristol-myers Squibb Compnay

Erik M Stang

Robert Michael Borzilleri

Heidi L Perez

Kyoung S Kim

Yong Zhang

Andrew J Tebben

Liping Zhang

Gretchen M Schroeder

Donna Wei

Andrew Forrest Donnell

David K Williams

Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).

Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses

There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention. 

IAP antagonists

There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

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Sterling, VA, United States of America

Erik M Stang