Orthovita, Inc.

Vita Special Purpose Corporation

Zimmer Knee Creations, Inc.

Vita Licensing, Inc.

Other

Minnesota Mining and Manufacturing Company

Erik M Erbe

Charanpreet S Bagga

Antony Koblish

James Philip Murphy

Ronald S Sapieszko

Theodore D Clineff

Gina M Nagvajara

Peter F Sharkey

Charles F Leinberry

Steven B Cohen

David H Dychala

Gregory J Pomrink

Marissa M Darmoc

Maarten Persenaire

Michael W Paris

Jeffrey G Marx

James M Freid

Stephen G Gilbert

Marissa M Conrad

Robert J Chiasera, Jr

Delbert E Day

Matthew B Havener

Anthony J Ruggiero

Steven B Brown

Anthony M Wilkes

Jeffrey J Wicklund

Vasanth Prabhu

Joshua A Wojcik

Marina Richard

Antony Kobilish

James P Murphy

Anthony Koblish

The embodiments provide provides devices, instruments, and associated methods for treating joint pain. A joint is evaluated using magnetic resonance imaging to detect any defects in the subchondral bone. For example, using T2-weighted MRI images, bone marrow lesions or edemas can be identified, and using T1-weighted MRI images, associated regions of sclerotic bone adjacent to the bone marrow lesion can be identified. The treatment method may involve introducing a bone void filler material at the site to address the bone marrow lesion or edema, and/or drilling and inserting an implant to address the sclerotic bone, bone marrow lesion or edema, and insufficiency or stress fractures. An access path is mapped to a location in the subchondral region where the insufficiency fracture resides. The access path attempts to preserve an articular surface of the joint. A reinforcing member that stabilizes the insufficiency fracture is then implanted via the access path.

Method for treating joint pain and associated instruments

A spinal implant body, including a body volumehaving an inferior portionA, a superior portionB, and a central portionC disposed between the inferior and superior portionsA,B. The bodyfurther includes a first bioactive polymer portionA distributed throughout body volume, a second bioactive ceramic portionA distributed throughout the body volume, and a third interconnected pore network portionA (which may be filled with a fourth fugitive portionA) distributed throughout the body volume. The central portionC is less porous than the inferior and superior portionsA,B and the pores in the inferior portionA are on average larger than the pores in the central portionC.

Osteogenic and angiogenic implant material

Disclosed is directed to a method for restoring bone in an animal comprising: accessing a site to be restored; loading a syringe body with a flowable bone graft material; mating the syringe body with a delivery tube; positioning the delivery tube at the site to be restored; using a syringe piston to advance the said material into the delivery tube; using the syringe piston or a plunger that mates with the delivery tube after removal of the syringe body to deliver the bone graft to the site at a force of less than 50 lbs. extrusion force; wherein said material is at least 75% porous with a mineral to polymer ratio of 80:20.

Method for restoring bone using shapeable bone graft substitute and instruments for delivery thereof

Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.

Bioactive load-bearing composites

Injectable bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.

Shapeable bone graft substitute and instruments for delivery thereof

The embodiments provide devices and methods that both strengthen the bone and stimulate the bone. Bone fractures or non-unions are stabilized, integrated or healed, which results in reduction of a bone defect, such as a bone marrow lesion or edema. In addition, the distribution of forces in a joint are restored or altered to relieve pain. In general, a joint is evaluated by taking an image of the joint and one or more subchondral defects are detected. At least one of the subchondral defects may be diagnosed as the source of pain and an extent of treatment for the subchondral defect is determined. The disclosed devices and techniques are particularly suited for treating chronic defects or injuries, where the patient's natural healing response has not resolved the defect. The present disclosure also provides several exemplary treatment modalities for the different extents of treatment needed.

Subchondral treatment of joint pain

A bioactive spinal implant used in cervical fusion, Anterior Lumbar Interbody Fusion (ALIF), Posterior Lumbar Interbody Fusion (PLIF), and Transforaminal Interbody Fusion (TLIF), having properties and geometries that enhance bone contact, stability, and fusion between adjacent vertebral bodies.

Bioactive spinal implants and method of manufacture thereof

Growing community of inventors

Berwyn, PA, United States of America

Erik M Erbe