Mayo Foundation for Medical Education and Research

Erik Leo Ritman

Amir Lerman

Timothy L Kline

Alexander C Langheinrich

Regina Moritz

A system and method for quantitative determination of density of vasa vasorum in an arterial wall that utilizes a detection of temporal and/or spatial displacement of blood-flow with the use of intravascular ultrasound system. Locations of extrema in the spatial distribution can be identified to detect vascular defects. The system and method support a clinically-useful application for early detection of indicators of diseases, such as coronary atherosclerosis.

Intravascular ultrasound detection of blood-flow distribution in an arterial wall

Two x-ray CT images are acquired of arterial plaque using x-rays at two different energy levels. The reconstructed images are normalized by adjusting pixel brightness until pixels depicting a region containing calcium have substantially the same brightness. The normalized images are subtracted to produce an image that depicts iron in the arterial plaque.

Method for imaging plaque using dual energy CT

A system and method for imaging a subject includes a clock that generates a clock signal and a radiation source that directs photons through the subject in response to the clock signal. A detector system is included that detects the photons and a memory module records a time of detection of the photons by the detector system with respect to the clock signal. The system includes a processor that calculates a time of flight (TOF) of the photons from the radiation source to the detector system and compares the TOF to a reference TOF to determine a delay in the TOF attributable to the photons passing trough the subject.

Growing community of inventors

Wabasha, MN, United States of America

Erik Leo Ritman