University of Utah Research Foundation

Other

University of Maine System

The Jackson Laboratory

Institut National De La Sante Et De La Recherche Medicale

Erik Jorgensen

Bruce A Bamber

Asim A Beg

Paola Nix

Steven P Callahan

Joerg Bewersdorf

Robert H Edwards

John M Schreiner

Sam Hess

Stan Kanarowski

Travis J Gould

Jordan Gerton

Tolga Tasdizen

Richard J Reimer

Brian Thomas Bennett

Josh Cates

Kim Schuske

Steven L McIntire

Tim Allen

Jason Martineau

Jean-Louis Bessereau

Mudalige Siyath Gunewardene

Shigeki Watanabe

Greg M Jones

Bryan W Jones

A phase plate for high precision wavelength extraction can include a planar substrate which has a point spread function engineered profile formed of a tessellation of regions. The point spread function engineered profile transforms a point spread function of a light source to form a wavelength dependent geometric pattern. The geometric pattern can also preserve spatial location information of the light source. Such a phase plate permits extracting three-dimensional position and the wavelength of a point emitter.

Phase plate for high precision wavelength extraction in a microscope

A method is described for correlating microscopy images from a number of modalities in a sub diffraction resolution environment. The method may include receiving a number of datasets that may represent microscopy captures from a number of different modalities. The microscopy captures may contain feature markers that may be used to register a number of data points contained in a dataset with data points from another dataset. Upon registering the data points of the datasets, a combined dataset may be produced and a visual image of the combined dataset may be provided.

Microscopy visualization

A system () and method for creating three dimensional images using probe molecules is disclosed and described. A sample is mounted on a stage (). The sample has a plurality of probe molecules. The sample is illuminated with light, causing the probe molecules to luminesce. The probe luminescence can be split into at least four paths corresponding to at least four detection planes corresponding to object planes in the sample. The at least four detection planes are detected via a camera (). Object planes in corresponding recorded regions of interest are recorded in the camera (). A signal from the regions of interest is combined into a three dimensional image.

Microscopy system and method for creating three dimensional images using probe molecules

The invention relates to an isolated or recombinant Na/Hexchanger comprising an isolated or recombinant Na/Hexchanger, particularly to the PBO-4 Na/Hexchanger. Also disclosed is an isolated or recombinant protein component of an H-gated channel which can be affected by extracellular Caconcentration. In particular, the invention relates to PBO-5 and/or PBO-8 and/or a H-gated channel composed of PBO-5 and PBO-8. The invention relates to compounds isolated from a vertebrate organism, wherein said compounds comprise at least a part of a H-gated channel or Na/Hexchanger. The invention also relates to a method for identifying a component of a H-gated channel in a vertebrate organism.

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The present invention relates to the field of GABA receptor structure and function. In one aspect, the present invention relates to impairment of the gamma-aminobutyric acid (GABA) receptors in parasitic nematodes, for the purpose of crop protection and/or soil treatment. The invention includes mutated nematode GABA receptor subunits, nematode GABA neuromuscular junction receptor complexes, nucleic acids which encode the mutated and functional receptor complexes, antibodies which selectively bind the GABA receptor complexes and/or subunits, and assays for compounds which adversely affect nematode GABA neuromuscular junction receptor function. The present invention therefore relates broadly to recombinant DNA technology, molecular biology tools, and crop protection and/or soil treatment.

Nematode neuromuscular junction GABA receptors and methods related thereto

The present invention provides methods for generating and identifying mutations in. Disclosed herein are methods for introducing DNA into thegermline, methods for expressing DNA in thegermline, and methods for generatingmutants by using controlled mobilization of endogenous and heterologous transposons. Also disclosed are a transgene construct for expression inand methods for inserting single copy DNA sequences into thegermline, and engineering mutations into thegenome.

Method of transposon-mediated mutagenesis in the nematode caenorhabditis elegans

Nematode neuromuscular junction GABA receptors subunits

Disclosed are invertebrate and vertebrate synaptic vesicle amino acid transporter compositions which define a novel family of transporter proteins, recombinant vectors and cells comprising nucleic acid sequences encoding vertebrate synaptic vesicle amino acid transporter proteins and antibodies directed against such proteins. Also disclosed are methods for utilizing such compositions in screening assays and treatment regimens.

Vesicular amino acid transporter composition and method

Growing community of inventors

Salt Lake City, UT, United States of America

Erik Jorgensen