Leo Pharmaceutical Products Ltd. A/s

Leo Pharmaceutical Products Ltd. A/s (lovens Kemiske Fabrik

Leo-pharma A/s

Erik Johannes Didriksen

Gert H&oslash;y

Gert Hoy

Gert Høy

The present invention relates to a pharmaceutical gel composition for application on skin, said composition comprising at least one vitamin D or vitamin D analogue and at least one corticosteroid as well as a viscosity-increasing excipient.

Topical composition

A pharmaceutical composition for dermal use, wherein the composition has a first pharmacologically active component A consisting of at least one vitamin D or vitamin D analogue, and a second pharmacologically active component B consisting of at least one corticosteroid, wherein the difference between the maximum stability pH of said first component A and the maximum stability pH of said second component B is at least 1. The composition can also have at least one solvent component C, where component C is compounds of the general formula R (OCH C(R )H) OR (I), wherein x is in the range of 2-60, R in each of the x units independently is H or CH , R is straight chain or branched C alkyl or benzoyl, and R is H or phenylcarbonyloxy; di-(straight or branched)-C alkyl esters of C -C dicarboxylic acids; straight or branched C -alkyl benzoates; straight or branched C -alkyl esters of straight or branched C -alkanoic or -alkenoic acids; propylenglycol diesters with C -alkanoic acids; and branched primary C alkanols.

Pharmaceutical composition

New pharmaceutical preparation containing pinacidil (N'-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine) in slow-release form, providing more uniform absorption rates and resulting blood levels when administered to the individual patients.

Growing community of inventors

Ballerup, Denmark

Erik Johannes Didriksen