Pharmacia & Upjohn Aktiebolag

Pfizer Corporation

Pharmacia & Upjohn Company

Esperion Therapeutics, Inc.

Kabi Pharmacia Aktiebolag

Erik Holmgren

Mats Lake

Cesare Sirtori

Peter Lind

Bjorn Nilsson

Jonas Ekblom

Joanna Chmielewska

Guido Franceschini

Timothy Wood

Lars B Abrahmsen

Mathias Uhlen

Bj&ouml;rn M Nilsson

Torsten Sejlitz

ANGsa Mikaelsson

Christina Kalderen

Lars Abrahamsen

Lars Abrahms&eacute;n

Mats Kihl&eacute;n

Mats Kihlén

Bjorn Lowenadler

The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using all of the foregoing.

Matrix metalloproteinase polypeptide

Matrix metalloproteinases

Substantially pure dimers of Apolipoprotein AI-Milano (APO-AI-M/APO AI-M) were isolated from plasma and characterized. Apolipoprotein AI-M dimer can also be produced in a recombinant system. Pharmaceutical compositions comprising the ApoAI-AI-M/ApoAI-M are described. Patients with atherosclerosis or cardiovascular diseases can be treated with the dimer. Medicaments containing the dimer can also be used to prevent thrombosis in different clinical circumstances, both at the arterial and at the venous level. The dimer can also act as a prodrug for the monomer.

Dimer of molecular variant of apolipoprotein and processes for the production thereof

Dimer of molecular variant of apolipoprotein and processes for the

Expression system for producing apolipoprotein AI-M

A process for preparing antibodies specific for an amino acid sequence which comprises immunizing a mammal with a fused protein comprising said amino acid sequence fused to an immunogenic IgG binding protein is disclosed.

Preparation of fused proteins, antibodies and processes therefore

Growing community of inventors

Lidingo, Sweden

Erik Holmgren