Basf Aktiengesellschaft

Morphochem Ag

Erik Henke

Uwe Bornscheuer

Ludger A Wessjohann

Wouter Kuit

Romano Orru

Hong Yang

Gunther Scheid

Yang Hong

The present invention is directed to novel acyloins, their derivatives, methods for their production and their use for the production of novel epothilones and their derivatives. In addition, the invention is directed to the building blocks for epothilone synthesis, methods for their production and the use of synthetic building blocks for the production of epothilones and their derivatives.

EPOTHILONE SYNTHESIS BUILDING BLOCKS III AND IV: ASYMMETRICALLY SUBSTITUTED ACYLOINS AND ACYLOIN DERIVATIVES, METHODS FOR THEIR PRODUCTION AND METHODS FOR THE PRODUCTION OF EPOTHILONES B, D AND EPOTHILONE DERIVATIVES

The present invention relates to a process for the preparation of stereoisomeric carboxylic acid esters consisting of an acid and of an alcohol component each having at least one chiral center, at least one stereoisomer of the carboxylic acid ester being present in an excess, by reacting a racemic carboxylic acid ester with a racemic alcohol in the presence of a carboxyl ester hydrolase (EC 3.1.1).

Process for preparation to stereoisomeric carboxylic acid esters

The invention relates to a process for the resolution of esters of arylalkylcarboxylic acids of the general formula

Process for the resolution of esters of arylalkylcarboxylic acids

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Stuttgart, Germany

Erik Henke