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Aktiebolaget Leo

Erik G Christensson

Aina L Abramo

Knut G Olsson

Anders K Bjork

Tomas Fex

Sven E Hernestam

Bengt K Gustafsson

Kjell B Martinsson

Nils-Goran E Olsson

Torbjorn E Lundstedt

Bisphenylalkylpiperazine derivatives, a method of their preparation and

A series of 1-piperazinecarboxamide derivatives of the following formula: ##STR1## The compounds of the present invention are neuropharmacological agents intended for the treatment of mental disorders, such as psychoses and depression.

Novel 1-piperazinecarboxamide derivatives

Piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side

This invention relates to a method for treating human beings and animals suffering from mental disorders comprising administering to said human beings and animals an effective amount of a compound for the treatment of such mental disorders comprising a compound having the formula ##STR1## wherein R is alkyl straight or branch chained having from 1 to 10 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms, aralkyl having from 7 to 9 carbon atoms or phenyl unsubstituted or substituted by one to three F, Cl, Br, lower alkyl having from 1 to 5 carbon atoms, lower alkoxy having from 1 to 5 carbon atoms, alkylenedioxy having from 1 to 3 carbon atoms, --CF.sub.3 or --CN substituents, R.sub.1 -R.sub.4 are independently H, CH.sub.3, C.sub.2 H.sub.5 with cis or trans configuration provided that only two of them are other than hydrogen, and pharmaceutically acceptable salts thereof.

Method of treating aggressive behavior and psychotic conditions

1-piperazinocarboxylates and pharmaceutical compositions containing them

Diphenylbutyl-1-acylpiperazines

Compounds having the general formula ##STR1## as herein defined and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions containing said compounds. Methods of treatment of humans and animals by such compounds and compositions.

Diphenylbutyl-piperazinecarboxamides to treat pain

Diphenylbutyl-piperazinecarboxamides in pharmaceutical compositions and

A method of treating diarrhoea and promoting weight gain in mammals by administration of an effective amount of a compound selected from the group consisting of 4-fluoro-.gamma.-(4-alkylpiperidino)-butyrophenone of the formula ##STR1## wherein R is lower alkyl having 1 to 6 carbon atoms, or pharmaceutically acceptable acid addition salts thereof.

Method of treating diarrhoea with gamma-piperidino-butyrophenones

Diphenylbutyl-piperzinecarboxamides

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Lund, Sweden

Erik G Christensson