Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Other

Efrudec Gmbh

Erich Wunsch

Eckart Wunsch

Udo Wunsch

Luis Moroder

Gerhard Ruhenstroth-Bauer

Gunter Valet

Ernst Jaeger

Gerhard Wendlberger

Hans Stocker

Regine Scharf

Karl-Heinz Deimer

A method for the removal or dispensing of liquids from containers, especially for the tapping of beer, in which pursuant to the quantity of liquid withdrawn, air is introduced into the container for pressure compensation or for the generating of an atmospheric pressure. Furthermore, also disclosed is a device for the dispensing of liquids from containers, especially a beer tapping device which is exchangeably connectable with the containers for effecting the withdrawal of the liquids and which essentially possesses a unitarily or multi-part constructed removal housing including a liquid-withdrawing tap, as well as passageways, bores, conduits or the like for the removal of the liquid and for the infeed of air.

Method and device for taking-out of fluids from containers

The invention relates to a hinge peptide of the general formula I that may e utilized for the manufacture of synthetic immunogens. The invention also comprises a process for the manufacture of this hinge peptide and a process for the manufacture of synthetic immunogens, where the hinge peptide is employed as a carrier protein.

Hinge peptide, a process for its manufacture, and its use for the

A spray container or can which possesses a spray mechanism for finely atomizing fluids through the intermediary of a hydraulically-operating pump. Containers such as spray cans and spary bottles or flasks of the above-mentioned type generally known in commerce. Through the intermediary of mechanically actuatable pumps, in this instance there is sprayed a finely atomized fluid from a nozzle which is arranged on a housing of the container. The spary mechanism is inserted into a housing which is connectable with the supply container for the spray fluid or liquid through a close-fitted or frictional locking connection, and in which the spray mechanism incorporates an electromotively driven gear pump, and in which the suction line of the pump is conducted through an opening in the bottom of the housing into the supply container, the latter of which is equipped with a venting line, whereby the gear pump includes a delivery or pressure tube at its output end which is connected with a discharge nozzle.

Spray container

A process for determining the pH value in the interior of a cell is descrd. This is accomplished by measurement of the emission of a fluorescent substance which is absorbed by the cell through incubation in a solution. The solution contains a compound of the said fluorescent substance; the fluorescent substance is separated from this compound in the cell by an enzyme present in the cell. The fluorescent substance selected is one such that the frequency of the emission maximum is dependent on the pH value. The compound of this fluorescent substance which is selected is one which is membrane penetrating. Measurement of the fluorescence is based on the principle of measurement of the frequency at which the emission maximum occurs. A fluorescent substance suitable for this purpose is 2,3-dicyano-1,4-hydroquinone. A suitable membrane penetrating compound is 1,4-diacetoxy-2,3-dicyanobenzene or 1,4-dibutyryloxy-2,3-dicyanobenzene or 1,4-di(-tert-butyloxycarbonyl-1-alanyloxy)-2,3-dicyanobenzene.

Process for determining the pH value in the interior of a cell

This invention relates to an apparatus providing rapid adjustment of a mirror which is pivotable about a vertical axis and retained in a housing, especially a vehicle rear view mirror, whereby the mirror is operated by an actuator having movement separated from the axis of rotation of the mirror itself and causing the mirror to rotate beyond its preset adjustment position through a preset angle, the mirror retaining contact which the actuator by means of a spring element. Movement of the actuator is controlled by a rotatable operating disk having a peripheral control curve. As the operating disk rotates, it passes through a movement arc which determines the movement of the actuator and the pivot angle of the mirror; this arc is followed by a rest phase arc which determines the final adjustment position of the actuator and the mirror; this arc is followed by a return arc which controls the return of the mirror and the actuator to their initial adjustment positions; the duration, extent and limits of the pivoting movement are all controlled by the configuration of the operating disk.

Apparatus providing rapid adjustment of a mirror

The invention concerns new 1-tert.-alkyl-thiohydrazine-1,2-dicarboxylic a derivatives, their production, and their use as reagents for the transfer of a 1-tert.-alkylthio residue, particularly of a 1-tert.-butylthio residue as a protective group for thiols.

Thiohydrazine-1,2-dicarboxylic acid derivatives and process for their

A process for determining the pH value in the interior of a cell is described. This is accomplished by measurement of the emission of a fluorescent substance which is absorbed by the cell through incubation in a solution. The solution contains a compound of the said fluorescent substance; the fluorescent substance is separated from this compound in the cell by an enzyme present in the cell. The fluorescent substance selected is one such that the frequency of the emission maximum is dependent on the pH value. The compound of this fluorescent substance which is selected is one which is membrane penetrating. Measurement of the fluorescence is based on the principle of measurement of the frequency at which the emission maximum occurs. A fluorescent substance suitable for this purpose is 2,3-dicyano-1,4-hydroquinone. A suitable membrane penetrating compound is 1,4-diacetoxy-2,3-dicyanobenzene or 1,4-dibutyryloxy-2,3-dicyanobenzene or 1,4-di(-tert-butyloxycarbonyl-1-alanyloxy)-2,3-dicyanobenzene.

Compounds for determining the pH value in the interior of a cell

Peptides having the carboxyl terminated sequence of the pancreozymin-cholstokinin 25-33 modified such that the amino acid group 25 carries a strongly basic group, the amino acid group 28 exhibits a hydrophilic character similar to that of the hydroxyamino acids and the amino acid group 31 exhibits a strongly hydrophobic character similar to that of amino acids with aliphatic side chains, and in particular nonapeptides having the sequence H--X--Asp--Tyr(SO.sub.3 H)--Y--Gly--Trp--Z--Asp--Phe--NH.sub.2 wherein X is arginine, homoarginine, norarginine, N.sub..epsilon.,N.sub..epsilon. -dialkyllysine, N.sub..delta. or N.sub..delta. -dialkyl-ornithine, Y is threonine, serine or hydroxy-proline and Z is norleucine, leucine, norvaline or .alpha.-amino-butyric acid, possess pronounced pancreozymin activity and can be employed in pharmaceutical preparations for controlling the function of the gall bladder and for controlling the enzyme secretion of the pancreas. Tyrosine-O-sulfate-barium salt and its N-acyl derivatives can be used as intermediate products for the preparation of peptides. For introducing the amino acid group 27 an N-acyltyrosine is reacted with an excess of pyridine--SO.sub.3 in a polar organic solvent, the resulting solution is extracted with water, the barium salt of the N-acyl-tyrosine-O-sulfate is precipitated from the aqueous phase by addition of a soluble barium compound, possibly the acyl group is split off in conventional manner, and the resulting tyrosine-O-sulfate-barium salt or its acyl derivative are processed employing the usual methods of peptide synthesis.

Method for preparing peptides and intermediate products

A remote-controlled rear-view mirror assembly having a mirror is movably supported in a housing and can be adjusted by an electric motor from a remote point. An electric motor is mounted in the mirror housing and has an electrically reversible direction of rotation and a stepdown gearing. There is a drive shaft having approximately at its center a driven coaxial cylinder of enlarged diameter with respect to the diameter of the drive shaft and a central annular shoulder dividing the coaxial cylinder into two substantially equal sections. A slipping clutch connects the motor with the drive shaft. Two eccentrics are rotatably mounted on the drive shaft on opposite sides respectively of the equal sections of the coaxial cylinder, each of these eccentrics comprises a cylindrical section and an eccentric disc. There are two wrap springs each of these wrap springs being wound in the same direction partly on one of the two equal sections and partly on one of the two cylindrical section of the eccentrics respectively. A transmission means connects the eccentric discs respectively to the mirror.

Rear view mirror adjustable by electric motor

Peptides having the carboxyl terminated sequence of the pancreozymin-cholstokinin 25-33 modified such that the amino acid group 25 carries a strongly basic group, the amino acid group 28 exhibits a hydrophilic character similar to that of the hydroxyamino acids and the amino acid group 31 exhibits a strongly hydrophobic character similar to that of amino acids with aliphatic side chains, and in particular nonapeptides having the sequence H--X--Asp--Tyr(SO.sub.3 H)--Y--Gly--Trp--Z--Asp--Phe--NN.sub.2 wherein X is arginine, homoarginine, norarginine, N.sub..epsilon.,N.sub..epsilon. -dialkyllysine, N.sub..delta. or N.sub..delta. -dialkyl-ornithine, Y is threonine, serine or hydroxy-proline and Z is norleucine, leucine, norvaline or .alpha.-amino-butyric acid, possess pronounced pancreozymin activity and can be employed in pharmaceutical preparations for controlling the function of the gall bladder and for controlling the enzyme secretion of the pancreas. Tyrosine-O-sulfate-barium salt and its N-acyl derivatives can be used as intermediate products for the preparation of peptides. For introducing the amino acid group 27 an N-acyl-tyrosine is reacted with an excess of pyridine-SO.sub.3 in a polar organic solvent, the resulting solution is extracted with water, the barium salt of the N-acyl-tyrosine-O-sulfate is precipitated from the aqueous phase by addition of a soluble barium compound, possibly the acyl group is split off in conventional manner, and the resulting tyrosine-O-sulfate-barium salt or its acyl derivative are processed employing the usual methods of peptide synthesis.

Peptides

A setting or adjusting device for rearview mirrors with a mirror plate secured to an arm which is pivotal both about a substantially vertical axis and about a substantially horizontal axis, yet is mounted non-rotatably in an axis perpendicular to the two axes, on a mirror holder. An adjusting unit engages the arm acting against a return spring, and comprises two tongs-like members rotatably mounted on the mirror holder about a common axis. The tongs-like members have first legs which accommodate the arm between them, and second legs which cooperate respectively with a controllable adjusting drive such a manner that a pivotal movement of the first legs respectively takes place about the common axis so that a displacement of the arm which is guided between the two first legs occurs which is transmitted in the form of a tilting movement about the horizontal and vertical axes respectively to the mirror plate.

Setting or adjusting means for rearview mirrors of motor vehicles

A setting and adjusting device for rearview mirrors mounted on a vehicle body comprising a mirror housing adapted to be mounted on the vehicle body and a mirror plate having a rear surface and a front reflecting surface. The mirror plate is adjustably mounted in the housing for pivoting and tilting of the mirror plate about a substantially vertical axis and a substantially horizontal axis, respectively. End stops limit the pivoting and tilting of the mirror plate. Controllable adjusting devices upon actuation and release thereof, respectively, pivot and tilt the mirror plate about the horizontal and vertical axes into predetermined lateral and vertical positions, respectively, and against the stops, respectively. A pivot lever and a bearing head, respectively, are operatively mounted to the mirror plate so as to positively engage the mirror plate in a pivot and tilt direction, respectively, and so as to be freely moveable relative to the mirror plate in a non-pivoting and non-tilting direction, respectively. Frictional slip couplings independently connect the pivot lever and the bearing head to an associated adjusting device, respectively.

With a remote controllable rearview mirror for vehicles or the like, the mirror plate is suspended without play by means of pivotally-moveable articulations on at least two, preferably three points, which points are arranged spaced from one another, whereby one suspension point is stationary and connected rigidly with the mirror housing, while one or the other suspension points is fastened respectively on one swingable arm, which arm simultaneously can be formed as a transmission member of the control device, and is constrained for guidance in the plane of pivoting under friction such that there is present a quasi-rigid connection of the mirror plate with the mirror housing.

Remote controllable rearview mirror

A radioiodinated phloretyl-.beta.-alanyl-secretin, its salts and its protected derivatives. A process for the manufacture of a radioiodinated phloretyl-.beta.-alanyl-secretin and/or a salt thereof which process involves reacting phloretyl-.beta.-alanyl-secretin and/or a salt thereof with radioactive iodine. Phloretyl-.alpha.-alanyl-secretin, its salts and its protected derivatives. A method for the determination of secretin in a sample, which involves; mixing the sample with a known amount of a radioiodinated phloretyl-.beta.-alanyl-secretin and an antibody specific for secretin; measuring the degree of binding of the labelled radioiodinated phloretyl-.beta.-alanyl-secretin; and determining the amount of secretin present in the sample by comparing the degree of binding with a standard curve which has been obtained by adding known amounts of secretin to a defined mixture of the radioiodinated phloretyl-.beta.-alanyl-secretin and the antibody and determining the degree of binding for this known amount of secretin.

Phlorethyl-.beta.-alanyl-secretine

An adjusting device for rearview mirrors of vehicles for covering rearward and lateral traffic conditions. Mounted off-center on opposite sides in a mirror housing are a mirror plate and a controllable adjustment device by which the mirror plate is simultaneously pivotable about vertical and horizontal axes. In a rest position the mirror plate rests against stops in predetermined lateral and vertical positions.

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Bad Liebenzell, Germany

Erich Wunsch