Leland Stanford Junior University

Erich S Uffelman

James P Collman

Xumu Zhang

The invention includes a water-soluble oxygen carrier. The oxygen carrier includes a meso-.alpha.,.alpha.,.alpha.,.alpha.-tetrakis(o-propanoylamino)phenylporph yrin, in which the 3-carbons of the propanoyl groups are each covalently bound to an amine nitrogen, and iron or cobalt is bound to the pyrrole nitrogens of the porphyrin. The oxygen carrier also includes a ligand L for protecting the open face of the porphyrin from .mu.-oxo dimer formation.

Tetraphenylporphyrin compounds and method

Disclosed is a metalloporphyrin-ligand complex which includes (a) a meso-tetraphenylporphyrin, (b) a crown ether rigidly attached to the meso-tetraphenylporphyrin by covalent attachment on one side of the porphyrin to two diagonally opposing phenyl groups, (c) a metal bound to the pyrrole nitrogens of the porphyrin, (d) a bridge covalently linking two diagonally opposing phenyl groups on the other side of the porphyrin, effective to hinder .mu.-oxo diner formation, and (e) a ligand having (i) a primary amine which is held noncovalently by the crown ether and (ii) a metal-coordinating atom which is coordinately bound to the metal. In another aspect, the invention includes a water-soluble oxygen carrier. The oxygen carrier includes a meso-.alpha.,.alpha.,.alpha.,.alpha.-tetrakis(o-propanoylamino)phenylporph yrin, in which the 3-carbons of the propanoyl groups are each covalently bound to a quaternary amine, and iron or cobalt is bound to the pyrrole nitrogens of the porphyrin. The oxygen carrier also includes a ligand L for protecting the open face of the porphyrin from .mu.-oxo dimer formation.

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Menlo Park, CA, United States of America

Erich S Uffelman