Boehringer Ingelheim Gmbh

Dr. Karl Thomae Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Karl Thomae Gmbh

Erich Muller

Josef Nickl

Berthold Narr

Walter Haarmann

Josef Roch

Johannes M Weisenberger

Armin Heckel

Wolfgang Eisert

Thomas Muller

Wolfgang Schroter

Rainer Zimmermann

Rudolf Kadatz

Gunther Engelhardt

Willi Diederen

Josef Nickl, Deceased

Helmut Ballhause

Johannes-Maximilian Weisenberger

Benthold Narr

Robin G Shanks

This invention relates to pharmaceutical compositions containing quinolin-2,5-diones of formula ##STR1## wherein A, B, R.sup.1 to R.sup.3 and X are defined hereinbelow, some of which are novel, which compounds have valuable pharmacological properties, particularly analgesic antipyretic and/or antiphlogistic effects, to new intermediates and processes for preparing them.

Pharmaceutical compositions containing quinolin-2,5-diones, new

The invention relates to new sulphonamidoethyl compounds having valuable pharmacological properties, particularly anti-thrombotic properties, and which are also thromboxane antagonists.

Sulphonamidoethyl compounds and pharmaceutical compositions comprising

The invention relates to new benzenesulphonamidoindanyl compounds useful in the treatment and prophylaxis of thromboembolic diseases, arteriosclerosis and tumor metastasis.

Benzenesulphonamidoindanyl compounds

The invention relates to new sulphonamido-ethyl compounds having the following structure: ##STR1## wherein R.sub.1 is substituted or unsubstituted phenyl, benzyl, nitrophenyl, acetamidophenyl or thienyl, R.sub.2 is hydroxycarbonyl or alkoxycarbonyl bonded via alkylene or alkenylene, or a 4,5-dihydro-pyridazin-3-one-6-yl or pyridazin-3-on-6-yl group optionally substituted on a ring carbon by C.sub.1 -C.sub.3 alkyl and X is substituted or unsubstituted imino, oxygen or sulphur, which compounds may be used to prevent arteriosclerosis or tumor metastasis, and are antitrombotic and thromboxane antagonists.

Sulphonamidoethyl compounds, pharmaceutical compositions comprising

The invention relates to new benzenesulphonamidoindanyl compounds having the following formula ##STR1## wherein the substituents are defined herein useful in the treatment and prophylaxis of thromboembolic diseases, arteriosclerosis and tumor metastasis.

Benzenesulphonamidoindanyl compounds, medicaments thereof, and processes

Compounds of the formula ##STR1## wherein R.sub.1 is a substituted alkoxy group, or an optionally substituted mercapto or amino group,

2-(perhydro-1,4-diazino)-pyrimido[5,4-d]-pyrimidines and salts thereof

The invention relates to new compounds of general formula ##STR1## wherein R.sub.1 represents an alkyl group,

8-alkylthio-2-piperazino-pyrimido[5,4-d]-pyrimidines

2-(Perhydro-1,4-diazino)-pyrimido(5,4-D)-pyrimidines, pharmaceutical

This invention relates to a compound of formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy; and R.sub.3 is a C.sub.7 -C.sub.9 aralkyl, the phenyl nucleus of which can be mono-, di-, or trisubstituted by halogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy, and nontoxic, pharmaceutically acceptable salts thereof. The compounds have useful antithrombic properties.

Quaternary 3,4-dihydro-isoquinolinium salts

The present invention relates to novel indolinones of the general formula ##STR1## wherein R represents an aryl group having from 6 to 10 carbon atoms, unsubstituted or mono- or disubstituted by alkyl groups having from 1 to 5 carbon atoms, hydroxyl groups, alkoxy groups having from 1 to 3 carbon atoms, or halogen atoms, whereby the substituents may be the same or different and whereby the phenyl nucleus of the aryl group may also be substituted by an amino group, a hydroxyl group, or an alkanoylamino group with altogether from 1 to 3 carbon atoms; an aryl group having from 6 to 10 carbon atoms, substituted by 3 or 4 alkyl groups having from 1 to 5 carbon atoms each; a phenyl group substituted by a phenyl, halogenphenyl, or cycloalkyl group with 5 to 7 carbon atoms; an aralkyl group having from 7 to 11 carbon atoms; or a pentamethylphenyl, pyridyl, or quinolyl group; m represents the number 0, 1, or 2; and n represents the number 2, 3, 4, 5, or 6.

Indolinones and pharmaceutical compositions containing same

Compounds of the formula ##STR1## wherein R.sub.1 is phenylalkylamino, alkylamino, dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino;

2-Piperazino-pteridines useful as antithrombotics and antimetastatics

Compounds of the formula ##STR1## wherein n is 0 or 1;

Antithrombotic sulfoximino carbostyrils

Antithrombotic use of 2-(perhydro-1,4-diazino)-pyrimido

This invention is directed to novel benzoxazin-2-ones of the formula ##STR1## wherein A is a sulfur atom or an SO, SO.sub.2, R--N.dbd.S, or R--N.dbd.SO.sub.2 group where R is a hydrogen atom or an acyl group;

Substituted benzoxazin-2-ones and pharmaceutical compositions containing

Compounds of the formula ##STR1## wherein R.sub.1 is optionally substituted alkyl;

Growing community of inventors

Biberach, Germany

Erich Muller