Schering Aktiengesellschaft

Schering Aktiengessellschaft

Erich Klieger

Heinz Gries

Heribert Schmitt-Willich

Hanns-Joachim Weinmann

Gabriele Schuhmann-Giampieri

Hubert Vogler

Ulrich Speck

Jurgen Conrad

Ulrich Niedballa

Bernd Raduchel

Eberhard Schroder

Wolfgang Mutzel

Julius Deutsch

Franz-Josef Renneke

Wolfgang Muetzel

Bernd Rad&uuml;chel

Juergen Conrad

Wolfgang Beich

J&uuml;rgen Conrad

Dieter Seidelmann

Bernd Raduechel

Peter Blaszkiewicz

DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production

Compounds of general formula I ##STR1## wherein Z.sup.1, Z.sup.2, X, R.sup.2 and R.sup.3 are as herein defined, are valuable pharmaceutical agents. In particular, the compounds are useful as contrast agents in NMR diagnosis.

DTPA monoamides, pharmaceutical agents containing these compounds, their

Chelate compounds of general formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and

DTPA monoamides for MRI

1. Compounds of general Formula I ##STR1## wherein n and m in each case mean the numbers 0, 1, 2, 3 and 4,

Substituted complexing agents, complexes, and complex salts, processes

Substituted polyamino, polycarboxy complexing agent dimers for MRI and

New triiodinated isophthalic acid diamides of the formula ##STR1## wherein the amide residues --CO--N.R.sub.1 R.sub.2 and --CO--N.R.sub.3 R.sub.4 are different from each other and

Novel triiodinated isophthalic acid diamides as nonionic X-ray contrast

Compounds of the formula ##STR1## wherein X is alkylene, optionally substituted by hydroxy, methoxy or amino;

Triiodinated aminoacetamido isophthalamide x-ray contrast agents

Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-4 alkyl, C.sub.1-4 alkyl substituted by OH or C.sub.1-2 alkoxy; R.sub.2, R.sub.3 and R.sub.4 are independently each hydrogen or C.sub.1-4 alkyl; Z is --A--NHCH.sub.3 or when R.sub.1 is hydroxy or alkoxy substituted alkyl and/or when R.sub.3 is lower alkyl, Z can also be hydroxy-C.sub.2-5 -alkylamino;

X-ray contrast media

Iodized isophthalamic acid compounds of the formula ##STR1## wherein R.sub.1 is straight-chain or branched lower hydroxyalkyl;

Novel iodized isophthalamic acid compounds

New amino acid derivative of acylamino-5-alkylcarbamoyl-2,4,6-triiodobenzoic acids are described together with processes for their preparation and use and novel intermediates useful in preparing these compounds. The compounds are valuable radiopaque agents useful as X-ray contrast media.

Triiodoisophthalic acid monoamino acid amides, process for the

Triiodoisophthalic acid monoamino acid amides

Growing community of inventors

Berlin, Germany

Erich Klieger