Hoffmann-la Roche Inc.

Erich Hochuli

Bernhard Eggimann

Reiner Gentz

Dietrich Stuber

Heinz Dobeli

Alfred Schacher

Paul Hadvary

Hans Lengsfeld

Ernst Kupfer

Karl Weyer

Urs Ettlin

Ernst K Weibel

The invention provides processes for producing Alpha-Interferon (IFN-.alpha.) free from possible mouse and/or virus contamination. The present invention further provides homogeneous IFN-.alpha. free from mouse and/or virus contamination and its use in antitumor and/or antiviral treatment.

Method for producing alpha-interferon

Fusion proteins and a process for their purification by means of metal chelate affinity chromatography on NTA resins are provided by this invention.

Affinity peptides

Adsorbents, which are suitable for the affinity chromatography of proteins, especially of interferons, and which consist of an electroneutral carrier matrix, --O--CH.sub.2 --CH(OH)--CH.sub.2 --NH- groups as the spacer and a triazine coloring substance bonded to the spacer.

Adsorbent for protein purification

Novel compounds of the formula ##STR1## wherein A signifies the group ##STR2## or --(CH.sub.2).sub.5 --, which inhibit pancreas lipase and can be used for the control or prevention of obesity and hyperlipaemia, are disclosed. The inventive compounds can be produced by the cultivation of microorganism Streptomyces toxytricini, identified as NRRL 15443.

Leucine derivatives

The purification of solutions of recombinant interferons is achieved by chromatography on metal chelate resins of the formula ##STR1## in which Me represents copper or nickel.

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Arisdorf, Switzerland

Erich Hochuli