Schering Aktiengesellschaft

Erich Gerhards

Rudolf Wiechert

Dieter Rahtz

Hans Wendt

Henning Koch

Peter Fuchs

Heinz Matthes

Inhalants comprising at least one corticoid of the general formula ##STR1## wherein --B--A-- is CH.sub.2 --CH.sub.2 --, CH=CH-- or CCl=CH--; X is a hydrogen atom, a fluorine atom, or methyl; Y is a hydrogen atom, a fluorine atom or a chlorine atom; Z is methylene, hydroxymethylene, fluoromethylene, a chloromethylene, or carbyl; R.sub.1 is a hydrogen atom or methyl and R.sub.2 is a hydrogen atom, or R.sub.1 and R.sub.2 collectivey are isopropylidenedioxy; and R.sub.3 is hydrocarbon of 1-12 carbon atoms, are useful for the treatment of allergic diseases of the respiratory tract.

Corticoid-containing inhalants

Bis-hydroxyphenylbutazone esters of alkanedioic acids of the formula ##SPC1## Wherein n is an integer from 1 to 18, inclusive; R.sub.1 is hydrocarbon of 3-9 carbon atoms, optionally substituted by oxo or interrupted by thia, sulfinyl, or sulfonyl; and R.sub.2 is a hydrogen atom, a fluorine atom, a chlorine atom, lower alkyl of 1-4 carbon atoms, or trifluoromethyl, preferably in the ortho or para position, possess topical anti-inflammatory activity.

Hydroxy phenylbutazone derivatives and their preparation

Growing community of inventors

Berlin, Germany

Erich Gerhards