The Scripps Research Institute

Emory University

Other

The University of Texas System

The Administrators of the Tulane Educational Fund

Zalgen Labs, LLC

Emergent Biosolutions Canada Inc.

Erica Ollmann Saphire

Robert F Garry

Rafi Ahmed

Thomas W Geisbert

James E Robinson

Luis Manuel Branco

Jody Berry

Carl Davis

Kathryn M Hastie

Luis M Branco

Disclosed herein are compositions comprising recombinant arenavirus monoclonal antibodies and antigen-binding fragments thereof, as well as therapeutic methods using the antibodies. In some embodiments, the antibodies provide pan-arenavirus protection against a number of arenavirus types and strains.

Arena virus monoclonal antibodies and uses

This disclosure relates to antibodies and antigen binding fragments that specifically bind Ebola virus particles. In certain embodiments, the antibodies and fragments are capable of treating or preventing an Ebola viral infection. In certain embodiments, the antibodies and antigen binding fragments are also contemplated for diagnostic methods and compositions related thereto.

Ebola virus antibodies and binding agents derived therefrom

Disclosed herein are compositions comprising arenavirus monoclonal antibodies, as well as therapeutic, diagnostic, and preventative methods using the novel antibodies. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules, peptides) that inhibit Old World arenavirus infectivity, including LASV and LCMV. In some embodiments, the antibodies provide pan-arenavirus protection against a number of arenavirus types and strains. Diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses are also disclosed, as well as new tools and methods for the design, production, and use of arenavirus monoclonal antibodies, including expression in engineered bacterial- and mammalian-based systems.

Arenavirus monoclonal antibodies and uses

Growing community of inventors

Solana Beach, CA, United States of America

Erica Ollmann Saphire