Celtaxsys, Inc.

Erica Brook Goodhew

Milton Henry Werner

Lopa Bhatt

Jonathan L Moon

Hyun Kang

Stacey L Rose

Scott Sacane

The present invention provides compositions and methods of controlling the direction and/or movement of migratory cells. Specifically, the invention is directed to the identification of novel chemorepellents and unimodal fugetaxins, their agonists and antagonists which alter or affect the movement of cells involved in immune, inflammatory or cancerous phenotypes.

Chemorepulsion of cells

The current invention is directed to methods of inducing the negative chemotaxis of a migratory cell comprising contacting the cell with a compound selected from the group consisting of idebenone, benazepril, rolipram, moxonidine, lamivudine, loxoprofen, terbinafine, Synephrine, 6-aminoindazole, and a Vitamin D analog, or a pharmaceutically acceptable salt of any of thereof.

Method of inducing negative chemotaxis

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Atlanta, GA, United States of America

Erica Brook Goodhew