W. L. Gore & Associates, Inc.

University of Delaware

Schering Corporation

E.i. Dupont De Nemours and Company

Dow Corning Corporation

Unilever Plc

Unilever, N.v.

Eric William Kaler

Huey Shen Wu

Ashit K Ganguly

Patricia C Weber

Larry D Ryan

Paul Reichert

William T Windsor

Randal Myron Hill

Martin Swanson Vethamuthu

Timothy D Krizan

Charles W McNemar

Orlin D Velev

James Alexander Silas

A Kamalakara Murthy

Beatriz E Rodriguez

Alexander Lips

Kavssery Parameswaran Ananthapadmanabhan

Matthew E Helgeson

Matthew W Liberatore

Norman John Wagner

Florian Nettesheim

This invention relates to pharmaceutical composition comprising a lipophilic oligosaccharide antibiotic in a substantially monomeric form.

Monomeric lipophilic oligosaccharide antibiotic compositions

The invention is a sensor for the presence of bio-specific (e.g., immunological) molecules. It is aimed to giving an alternative, highly advanced method for performing different tests for the presence of immuno-specific molecules in liquid environments such as body liquids, biological cultures, environmental samples, etc. Gold patterns are photolithoghraphyically fabricated onto glass substrates to form addressable electrodes of micron size. The sensor is assembled when colloidal particles from suspension are deposited dielectrophoretically in the microscopic gaps between the electrodes. The surfaces of these particles carry immuno-active binding sites that collect the target molecules. The sensor readout is accomplished by secondary tagging of the target molecules with colloidal gold and its enhancement by silver nucleation, which leads to short-circuiting of the electrodes. The device allows extreme miniaturization and direct electric readout. We anticipate detection levels as low as 10,M, which is a 200 times gain in sensitivity over the conventional techniques.

Miniaturized immunosensor assembled from colloidal particles between micropatterned electrodes

A microemulsion comprising: a functionalized hydrocarbon, an anionic surfactant, a diol having from 2 to 10 carbon atoms and water.

Aqueous microemulsions

A clear single phase composition contains 40-95% by weight of a cyclic or short chain linear methyl siloxane and water, and 5-60% by weight of a cationic surfactant and a nonionic surfactant. The cyclic or short chain linear methyl siloxane in the single phase composition has an average structure or droplet diameter of less than about 50 nanometer. The single phase composition spontaneously provides optically clear one phase silicone microemulsions when combined with only hand agitation. The clear single phase compositions are useful in personal care and textile applications.

Single phase silicone and water compositions

A method of analyzing pharmaceutically useful suspensions of lipophilic oligosaccharide antibiotics by QLS is disclosed.

Method of determining monomeric drug content

Aqueous microemulsions are described which are polymerized to produce a latex containing particles of organic polymer having recurring pendant perfluorinated organic side chains which have an average particle size of between 0.01 and 0.5 micrometers. The latex can be used to coat the surface of substrate structures, or to coat the pore walls of porous substrate structures.

Microemulsion polymerization systems and coated materials made therefrom

In this invention an aqueous colloidal dispersion of submicron size polymer particles is used to coat the internal structure that defines the pores of microporous substrates.

Process for coating microporous substrates and products therefrom

The formation of spontaneous, thermodynamically stable vesicles from surfactant solutions is described. The vesicles comprise at least one single-chain, anionic surfactant and at least one single-chain cationic surfactant. Use of the vesicles in ultrafiltration treatment of water is disclosed.

Spontaneous equilbrium surfactant vesicles

Growing community of inventors

Setauket, NY, United States of America

Eric William Kaler