Thomas Jefferson University

Bound Therapeutics, LLC

Smart Tech Ltd.

Eric Wickstrom

Hilary Koprowski

Bernhard Dietzschold

Javad Parvizi

Zhen Fang Fu

Noreen J Hickok

Christine Le Bec

Stephen Cleaver

Yuan-Yuan Jin

Soumitra Basu

The present invention provides compositions and methods of making and using MYC mRNA antisense inhibitors. In a particular embodiment, the invention features compositions and methods useful for the treatment of a condition (e.g., cancer).

Compositions and methods formessenger RNA inhibitors

Oligodeoxynucleotides complementary to genomic RNA of a negative-stranded nonsegmented RNA virus are provided. Methods of inhibiting infection of cells by a negative-stranded nonsegmented RNA virus and treating animals infected with a negative-stranded nonsegmented RNA virus using these oligodeoxynucleotides are also provided.

Antigenomic oligodeoxynucleotides for treatment of infection by negative-stranded nonsegmented RNA viruses

Peptide nucleic acid (PNA) oligomers are conjugated to a ligand which is capable of binding to a cell surface receptor. The ligand facilitates cellular uptake of the PNA oligomer. Where the ligand is a peptide, the conjugate may be produced as a unitary molecule by first synthesizing the peptide ligand by solid phase or solution peptide synthesis, followed by synthesis of the PNA oligomer as an extension of the peptide ligand. The PNA oligomer base sequence is selected to hybridize to a target polynucleotide sequence by either triplex (dsDNA) or duplex (ssDNA; RNA) formation.

Peptide nucleic acid conjugates

A vector containing a selected nucleic acid sequence interposed between the terminal ends of a Tn7 transposon and a method for site specific integration of genetic material into a chromosome using those vectors are provided.

Composition and method for targeted integration into cells

The present invention provides a method for producing an oligonucleotide having stereospecific substituted phosphonate linkages by use of a pentavalent Grignard coupling reaction on a solid phase support. The method can be used for automated synthesis of oligonucleotides having sequential equatorial or axial stereospecific substituted phosphonate linkages.

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Philadelphia, PA, United States of America

Eric Wickstrom