Acceleron Pharma Inc.

Other

University of California

Eric Werner

Ravindra Kumar

Asya Grinberg

Roselyne Castonguay

Kenneth N Raymond

Jide Xu

Evan G Moore

In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a truncated, ligand-binding portion of the extracellular domain of endoglin (ENG) polypeptide may be used to treat fibrotic disorders.

Endoglin peptides to treat fibrotic diseases

In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a truncated, ligand-binding portion of the extracellular domain of endoglin (ENG) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders.

Endoglin polypeptides and uses thereof

The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using the complexes of the invention.

Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides

The present invention pertains to an apparatus for shaving. The apparatus for shaving comprises at least one blade having an essentially straight and essentially continuous cutting edge. The blade is comprised of a plurality of pliable blade segments aligned adjacent to each other to form the cutting edge such that each blade segment is capable of deflecting in a direction perpendicular to the cutting edge independently with respect to the other blade segments. The apparatus is also comprised of a rectangular shaped head which holds the blade in a desired orientation. Additionally, the apparatus is comprised of a handle connected to the head. Preferably, the head holds the blade such that the blade segments are freestanding and not prestressed. In an alternative embodiment, the head can include a styptic strip disposed along the length of the head in parallel with the cutting edge and above the cutting edge such that after the cutting edge passes over the shaving surface during shaving, the styptic strip passes over the surface. Additionally, the head can include a lubricating strip disposed along the length of the head in parallel with the cutting edge and below the cutting edge such that before the cutting edge passes over the surface during shaving, the lubricating strip passes over the surface. In another preferred embodiment, the apparatus can include a styptic stick. In an even more preferred embodiment, the blade can have a plurality of holes whose centers are in spaced relationship with the cutting edge. The present invention also pertains to an apparatus for cutting.

Apparatus for cutting or shaving

The present invention pertains to an apparatus for shaving. The apparatus for shaving comprises at least one blade having an essentially straight and essentially continuous cutting edge. The blade is comprised of a plurality of pliable blade segments aligned adjacent to each other to form the essentially straight and essentially continuous cutting edge such that each blade segment is capable of being deflected in a direction perpendicular to the cutting edge independently with respect to the other blade segments by a surface while in contact with the surface during shaving of the surface. The apparatus is also comprised of a rectangular shaped head which holds the blade in a desired orientation. Additionally, the apparatus is comprised of a handle connected to the head. In a preferred embodiment, there can be two blades held in the head in a tandem relationship. Preferably, the head holds the blade such that the blade segments are freestanding and not prestressed.

Growing community of inventors

Milton, MA, United States of America

Eric Werner