Life Technologies Corporation

Eric Welch

Eric Tulsky

Joseph A Treadway

Joseph August Bartel

Yongfen Chen

Adam York

Kyle R Gee

Bruce Branchaud

Yi-Zhen Hu

Robert Aggeler

Xin Wang

Imad Naasani

Roman Rozhkov

John Matthew Mauro

Lawrence Greenfield

Michael Ignatius

David Bussian

Daniel Cash

Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.

Fluorescent particles

Refractive index matching (RIM) formulations, their use for mounting biological specimens (e.g., cells and tissues) to a substrate, and methods of visualizing biological specimens embedded in RIM formulations are described.

Refractive index matching formulations

A population of bright and stable nanocrystals is provided. The nanocrystals include a semiconductor core and a thick semiconductor shell and can exhibit high extinction coefficients, high quantum yields, and limited or no detectable blinking.

Nanocrystals with high extinction coefficients and methods of making and using such nanocrystals

Fluorogenic semiconductor nanocrystals and compositions thereof are provided herein, including kits, assay systems and methods for their preparation and use.

Fluorogenic semiconductor nanocrystals

A population of nanoparticles is disclosed. The population is comprised of a plurality of core/shell nanocrystals, each including: a semiconductor core, an intermediate semiconductor shell layer disposed over the semiconductor core, an external semiconductor shell layer disposed over the intermediate semiconductor shell layer, and a hydrophilic organic layer in direct contact with the external semi-conductor shell layer. The population of nanoparticles has a &#x3b1;value of less than about 1.4.

Stable nanoparticles and methods of making and using such particles

A nanoparticle having one or more phosphonates or phosphinate ligands on their surface can be converted into nanoparticles with sulfonate ligands on their surface, by contacting the phosphonate-containing nanoparticles with a silylsulfonate reagent. Such nanoparticles are activated toward reactions with nucleophilic groups; thus the method provides activated nanoparticles, and methods of making and using them to produce modified nanoparticles.

Sulfonate modified nanocrystals

Coated fluorescent semiconductor nanoparticles having an organic surface layer of multi-functional surface ligands that include a nanocrystal binding center and one or more covalently attached functional groups or reactive functional groups are described as well as water-dispersible nanoparticles having an organic surface layer or multi-functional surface ligands and methods for the preparation and use of such coated nanoparticles.

Growing community of inventors

Eugene, OR, United States of America

Eric Welch