Amazon Technologies, Inc.

Oracle International Corporation

Ariosa Diagnostics, Inc.

Tacit Knowledge Systems, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Eric Wang

David L Gilmour

Arnold Oliphant

Craig Struble

Andrew Sparks

Ronald Joseph Degges, Jr

Christopher D Coley

Jonathan Michael Goldberg

Hernan Epelman-Wang

Louis LeRoi LeGrand, Iii

Vijay Kamarshi

Amit Tikare

Renwei Yan

Sankara Narayana Hemanth Meenakshisundaram

Choudhary Omer Rafique

Nicolas Trown

Sanjukta Mitra

Andrew Hamel

Richard Sanders

Kerry H Scharfglass

The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.

Risk calculation for evaluation of fetal aneuploidy

The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.

Assay systems for genetic analysis

Assay systems for determination of source contribution in a sample

A speech recognition system that automatically sets the volume of output audio based on a sound intensity of a command spoken by a user to adjust the output volume. The system can compensate for variation in the intensity of the captured speech command based on the distance between the speaker and the audio capture device, the pitch of the spoken command and the acoustic profile of the system, and the relative intensity of ambient noise.

Matching output volume to a command volume

A method and system for knowledge management are disclosed. A plurality of profiles of entities are identified wherein the profiles comprise a shared characteristic. The contents of the plurality of profiles are added to a generated aggregate profile.

Expertise services platform

In a system that monitors the positions and movements of objects within an environment, a depth camera may be configured to produce depth images based on configurable measurement parameters such as illumination intensity and sensing duration. A supervisory component may be configured to roughly identify objects within an environment and to specify observation goals with respect to the objects. The measurement parameters of the depth camera may then be configured in accordance with the goals, and subsequent analyses of the environment may be based on depth images obtained using the measurement parameters.

Determining time-of-fight measurement parameters

In some examples, the intensity of an image projected onto a surface at an oblique angle may be controlled to equalize the intensity, and thereby to eliminate from the image perceptible variations in brightness. For instance, a first distance to a closer portion of the image and a second distance to a farther portion of the image may be used to determine an amount of change to be made to the intensity of at least one portion of the image. In some implementations, a filter may be used to control changes to the intensity of the image. In other implementations, the image information may be modified, such as on a pixel level, to control the intensity of the image.

Projection display intensity equalization

Described herein are systems and devices for mitigating multi-path interference in optical time-of-flight systems. An input surface is configured with a pattern comprising predominately low albedo material and a plurality of decimated high albedo features. The low albedo material is configured to minimize reflectance of light emitted by an emitter. The high albedo material is configured to reflect more of the light than the low albedo material. The low and high albedo materials, or an additional material, may be used to provide a high albedo material in visible light wavelengths, configured for use as a projection surface.

Multi-path reduction for optical time-of-flight

The present invention provides processes for determining more accurate risk probabilities for medical conditions. The risk probabilities of the presence or absence of a medical condition are calculated using frequency data from selected biomolecules and biomolecule source contribution of at least one source in a mixed sample.

Enhanced risk probabilities using biomolecule estimations

A method of constructing an entity profile, having private and public portions with different access restrictions, commences with the assignment of a confidence level to content within an electronic document. The electronic document may be associated with the first entity (e.g., may have been authored by or addressed to the first entity). The content may furthermore potentially be descriptive of the first entity. If the confidence level assigned to the content is less than a predetermined threshold, the content is automatically rejected for inclusion within the entity profile. On the other hand, if the confidence level assigned to the content exceeds the predetermined threshold, the content is included within the private portion of the entity profile. Thereafter, the content is automatically presented to the first entity for authorization, by the first entity, for inclusion of the content within the public portion of the profile. The public portion of the entity profile may be freely accessible by other entities, whereas the private portion may have access restrictions.

Method and apparatus for constructing and maintaining a user knowledge profile

A method of constructing an entity profile, having private and public portions with different access restrictions, commences with the assignment of a confidence level to content within an electronic document. The electronic document may be associated with a first entity. The content may be descriptive of the first entity. If the confidence level assigned to the content is less than a predetermined threshold, the content is automatically rejected for inclusion within the entity profile. If the confidence level assigned to the content exceeds the predetermined threshold, the content is included within the private portion of the entity profile. Thereafter, the content can be automatically presented to the first entity for authorization, by the first entity, for inclusion of the content within the public portion of the profile. The public portion of the entity profile may be freely accessible by other entities, whereas the private portion may have access restrictions.

A method of constructing an entity profile having private and public portions commences with the assignment of a confidence level to content within an electronic document. The electronic document may be associated with a first entity. The content may be descriptive of the first entity. If the confidence level assigned to the content is less than a predetermined threshold, the content is automatically rejected for inclusion within the entity profile. If the confidence level assigned to the content exceeds the predetermined threshold, the content is included within the private portion of the entity profile. Thereafter, the content can be automatically presented to the first entity for authorization, by the first entity, for inclusion of the content within the public portion of the profile. The public portion of the entity profile may be freely accessible by other entities, whereas the private portion may have access restrictions.

An agent in a knowledge management system automatically manages profile terms in a user profile by selecting certain terms in a private portion of the user profile and moving the selected terms to a public portion of the profile. Additionally, the selected terms can be further filtered to determine which will be moved. The owner of the user profile also may specify whether a particular term is always moved, never moved, or moved only when the user is alerted that the term is selected and the owner chooses to move the term.

Growing community of inventors

Milpitas, CA, United States of America

Eric Wang