Ariosa Diagnostics, Inc.

Nutanix, Inc.

Roche Molecular Systems, Inc.

Roche Sequencing Solutions, Inc.

Ariosa Diagnosis, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Eric Wang

Craig Struble

Arnold Oliphant

Kalpesh Ashok Bafna

Andrew Sparks

Manoj Premanand Naik

Anil Kumar Gopalapura Venkatesh

John Stuelpnagel

Yifeng Huang

Durga Mahesh Arikatla

Mausumi Ranasingh

Sanath Kumar Kalligundi Shivaswamy

Kavitha Pasikanti

Sanika Nitin Mokashi

Lakshmana Reddy

The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.

Assay systems for genetic analysis

Examples of systems described herein provide for share-level disaster recovery on, for example, virtualized file servers by enabling additional snapshots, including self-service recovery (SSR) snapshot migration in addition to replication snapshot migration to a disaster recovery location. In examples, a disaster recovery location may receive a replication of a share of a file system, the snapshot configured for recovery of the share at the disaster recovery location. The replication snapshot may include one or more additional snapshots, each taken since a time of a previous replication snapshot. At least one of the one or more additional snapshots may include an SSR snapshot, identifiable based at least on a tag associated with a process used to create the SSR snapshot at a primary location. The at least one additional snapshot may be extracted for use by another instance of the process at the disaster recovery location.

Self-service restore (SSR) snapshot replication with share-level file system disaster recovery on virtualized file servers

A file server manager disclosed herein accesses information regarding a selected share of a source distributed file server for replication, where the selected share stores at least a portion of a namespace of storage items and is hosted by a first file server virtual machine of the source distributed file server. The file server manager accesses a mapping between virtual machines of the source distributed file server and virtual machines of the destination distributed file server and replicates the selected share to a second file server virtual machine of the destination distributed file server based on the mapping. The file server manager directs a request to read a first storage item to the destination distributed file server and directs a request to write to a second storage item to the source distributed file server while the destination distributed file server services the request to read the first storage item.

Share-based file server replication for disaster recovery

Examples described herein include virtualized environments including a virtualized file server. Examples of file server virtual machine managers are described which may setup and/or configure file server virtual machines in accordance with a target number of connections and/or a target throughput for the virtualized file server. The virtualized file server may be scaled up, scaled down, scaled in, and/or scaled out.

Virtualized server systems and methods including scaling of file system virtual machines

The present invention provides methods for non-invasive determination of sex in a fetus or of Y chromosomal frequency abnormalities&#x2014;indicative of aneuploidy or sex mosaicisms in a fetus&#x2014;by detecting and determining the relative contribution genetic sequences from the Y chromosome in view of the percent fetal contribution in a maternal mixed sample.

Non-invasive fetal sex determination

The present invention provides assay systems and methods for determining the percent fetal contribution of cell-free DNA in a maternal sample from a pregnant female with an egg donor pregnancy. Further provided, are assay systems and methods for determining a statistical likelihood of the presence or absence of a fetal aneuploidy in a maternal sample using a determined percent fetal cell-free DNA in the sample.

Noninvasive detection of fetal aneuploidy in egg donor pregnancies

The present invention provides processes for calculating phased genomic sequences of the fetal genome using fetal DNA obtained from a maternal sample. The processes and systems of the present invention utilize novel technological and computational approaches to detect fetal genomic sequences and determine the phased heritable genomic sequences. The invention could be used, e.g., to identify in utero deleterious mutations carried by the parents and inherited by a fetus within a particular heritable genomic region.

Processes for calculating phased fetal genomic sequences

The present invention provides methods for non-invasive determination of X and/or Y chromosomal abnormalities indicative of aneuploidy or sex mosaicisms in a maternal sample by detecting and determining the relative contribution of genetic sequences from the X chromosome and/or the Y chromosome in the maternal sample.

Statistical analysis for non-invasive sex chromosome aneuploidy determination

The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.

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San Jose, CA, United States of America

Eric Wang