Siemens Medical Solutions Usa, Inc.

Asm IP Holding B.v.

Bss Technologies, Inc.

Other

Eli Lilly and Company

Ncr Corportation

Eric Wang

Joseph C Walsh

Gang Chen

Dhanalakshmi Kasi

Anjana Sinha

Hartmuth C Kolb

Umesh B Gangadharmath

Wei Zhang

Vani P Mocharla

Anna Katrin Szardenings

Chul Yu

Changhui Liu

Tieming Zhao

Peter J H Scott

Eric James Shero

Kai Chen

Robert Brennan Milligan

Fred Alokozai

Farhad Karimi

Dong Li

Melvin Verbaas

Jason D Geder

Marius Pruessner

William George Petro

Hao Wang

Luping Li

William C Sandberg

Qianwa Liang

Henry Clifton Padgett

Brian A Duclos

Zhiyong Gao

Chunfang Xia

Isamu Leonard Yamamoto

Michael Schaefers

Andreas Faust

Sven Hermann

Daniel Weis

Pragya Tripathi

Guenter Haufe

Harmuth C Kolb

Klaus Kopka

Verena Hugenberg

Stefan Wagner

Hans-Joerg Breyholz

Vani P Mocharia

Daniel Kurt Cashion

Peter Jh Scott

Peter JH Scott

Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

PSMA imaging agents

A vessel includes a body that floats in water. One or more thrusters and sensors are provided on the body. A controller is configured to selectively activate the thrusters to cause the vessel to move along a path through the water, receive sensor data from the one or more sensors while the vessel is moving along the path, determine, based on the sensor data, whether an obstacle or a dangerous condition is present in the water; control the thrusters to avoid the obstacle, and output a warning when the dangerous condition is present in the water. The collected sensor data may relate to locations and directions of currents in the water, the dangerous condition may relate to a rip current, and the warning may identify at least one attribute of the rip current. A map identifying a location of the dangerous condition may be generated and forwarded to other devices.

System for dangerous current identification, characterization, alerting and for distressed swimmer location and assistance

An apparatus and method for depositing a transition metal nitride film on a substrate by atomic layer deposition in a reaction space defined by an at least one chamber wall and showerhead is disclosed. The apparatus may include, a substrate support disposed within the reaction space, the substrate support configured for supporting at least one substrate and a temperature control system for controlling a temperature of the at least one chamber wall at those portions of the at least one chamber wall that is exposed to a vapor phase reactant. The apparatus may also include a temperature control system for controlling a temperature of the showerhead, wherein the temperature control system for controlling a temperature of the showerhead is configured to control the temperature of the showerhead to a temperature of between approximately 80° C. and approximately 160° C. The method may include, providing at least one substrate on a substrate support within the reaction space and controlling a temperature of the at least one chamber wall at least at those portions of the at least one chamber wall that is exposed to a vapor phase reactant and controlling a temperature of a showerhead. The method may also include, alternatively and sequentially feeding at least two vapor phase reactants into the reaction space, wherein the temperature of the showerhead is controlled to a temperature between approximately 80° C. and approximately 160° C.

Methods for depositing a transition metal nitride film on a substrate by atomic layer deposition and related deposition apparatus

An apparatus and method for depositing a transition metal nitride film on a substrate by atomic layer deposition in a reaction space defined by an at least one chamber wall and showerhead is disclosed. The apparatus may include, a substrate support disposed within the reaction space, the substrate support configured for supporting at least one substrate and a temperature control system for controlling a temperature of the at least one chamber wall at those portions of the at least one chamber wall that is exposed to a vapor phase reactant. The apparatus may also include a temperature control system for controlling a temperature of the showerhead, wherein the temperature control system for controlling a temperature of the showerhead is configured to control the temperature of the showerhead to a temperature of between approximately 80&#xb0; C. and approximately 160&#xb0; C. The method may include, providing at least one substrate on a substrate support within the reaction space and controlling a temperature of the at least one chamber wall at least at those portions of the at least one chamber wall that is exposed to a vapor phase reactant and controlling a temperature of a showerhead. The method may also include, alternatively and sequentially feeding at least two vapor phase reactants into the reaction space, wherein the temperature of the showerhead is controlled to a temperature between approximately 80&#xb0; C. and approximately 160&#xb0; C.

A vessel includes a body, such as surfboard, that floats in water. One or more thrusters, and one or more sensors are provided on the body. A controller is configured to selectively activate the thrusters to cause the vessel to move along a path through the water, receive sensor data from the one or more sensors while the vessel is moving along the path, determine, based on the sensor data, whether a dangerous condition is present in the water; and output a warning when the dangerous condition is present in the water. For example, the collected sensor data may relate to locations and directions of currents in the water, the dangerous condition may relate to a rip current, and the warning may identify at least one attribute of the rip current. A map identifying a location of the dangerous condition may be generated and forwarded to other devices.

Devices and methods for client application user experience tracking may include generating a user experience score based on tracked operation and user inputs to the client application. The user experience score is transmitted to an experience tracking service (e.g., remote computer server, locally executed application).

Client application user experience tracking

Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.

Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof

Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and &#x3b2;-amyloid peptides are presented herein. The invention also relates to methods of imaging A&#x3b2; and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.

Imaging agents for detecting neurological disorders

Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.

Imaging agents useful for identifying AD pathology

Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.

Imaging agents for detecting neurological dysfunction

A power- and/or manually- driven golf cart which is collapsible, without disassembly, into a compacted configuration for storing or transporting, and extendable, without assembly, into an operable or usable configuration for carrying a golf bag about a golf course. The golf cart includes a golf bag support frame, a pair of lateral support members pivotally connected to the frame and to a pair of ground support wheels, a power-driven wheel supported at the lower end of golf bag support frame, and a power drive mounted on the front side of the frame. A hinge is operably connected between a lower end of the upper frame member and an upper end of the lower frame member to permit the upper frame member and the lower frame member to be pivotally moved between a substantially aligned extended position and a substantially adjacent folded position. At least two connecting rods are pivotally connected at one end to the upper frame member and at their other ends to one of the lateral support members. When the upper frame member and the lower frame member are pivotally moved to a substantially aligned extended position, the ground support wheels are disposed outward from the golf bag support frame, and when the upper frame member and the lower frame member are pivotally moved to a substantially adjacent folded position, the ground support wheels are disposed closely adjacent to the golf support frame.

Power- and/or manually-driven collapsible golf cart

Golf cart handle cover

Growing community of inventors

San Diego, CA, United States of America

Eric Wang