Arrow International Limited

Semprus Biosciences Corporation

Eric W Marchese

Chad Cori Huval

Zheng Zhang

Christopher R Loose

Jun Li

Michael A Bouchard

Arthur J Coury

Laurence A Roth

Matt Skinner

Douglas J K Weaver

Douglas Weaver

Robert Reed

Abby N Deleault

Phu C Nguyen

Abbe Miller

Kobe Elias

Michael Bouchard

Catheters and a method of preparation thereof, the catheter comprising a catheter body, a juncture hub, extension lines and connectors, the catheter body having a proximal end, a distal end, an exterior surface, a tip region having a length of 10 cm measured from the distal end of the catheter body, and at least two lumen, each of the catheter body lumen having a proximal end, a distal end, a Lumen Aspect Ratio of at least 3:1, and an intraluminal surface, the distal ends of the at least two catheter body lumen being (i) non-coterminus or (ii) laser-cut, the exterior surface of the catheter body in the tip region or the intraluminal surface of the two catheter body lumen comprising a hydrophilic polymer layer having an Average Dry Thickness of at least about 50 nanometers.

Surface modification for dialysis catheters

Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.

Articles having non-fouling surfaces and processes for preparing the same without altering bulk physical properties

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Cambridge, MA, United States of America

Eric W Marchese