Darwin Discovery Limited

Ucb S.a.

Eric W Jeffery

Mary E Brunkow

Fred Ramsdell

Kathryn Hjerrild

Kathryn A Hjerrild

Isolated nucleic acid molecules are provided which encode Fkh, as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Utilizing assays based upon the nucleic acid sequences disclosed herein (as well as mutant forms thereof), numerous molecules may be identified which modulate the immune system.

Identification of the gene causing the mouse scurfy phenotype and its human ortholog

Isolated nucleic acid molecules are provided which encode Fkh , as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Utilizing assays based upon the nucleic acid sequences disclosed herein (as well as mutant forms thereof), numerous molecules may be identified which modulate the immune system.

Isolated nucleic acid molecules are provided which encode Fkh , as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Assays that are based upon the nucleic acid sequences disclosed herein (as well as mutant forms thereof), may be used for identifying numerous molecules that modulate the immune system. Molecules that specifically bind to an Fkh polypeptide are also provided as useful, such as, for modulating the biological activities of Fkh . In particular, antibodies that are specific for Fkh polypeptide are provided for uses such as for detecting the expression of an Fkh polypeptide in cells, isolating an Fkh polypeptide, and modulating the activity of an Fkh polypeptide.

Antibodies specific for Fkhsf gene products

Isolated nucleic acid molecules are provided which encode Fkh , as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Utilizing assays based upon the nucleic acid sequences disclosed herein (as well as mutant forms thereof), numerous molecules may be identified which modulate the immune system

Growing community of inventors

Seattle, WA, United States of America

Eric W Jeffery