Unibioscreen S.a.

Université Libre De Bruxelles

Eric Van Quaquebeke

Robert Kiss

Francis Darro

Jean-Claude Braekman

Pierre Guissou

Odile Germaine Nacoulma

Gentiane Simon

Janique Dewelle

Jérôme Tuti

Laurent Van Den Hove

Compounds and pharmaceutical compositions which include 2&#x2033; oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer.

2&#x2033; oxo-voruscharin and derivatives thereof

The present invention is directed to azonafide derivatives obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates, sulfonyl halides, monohalogenoalkanes, monohalogenoalkenes or monohalogenoalkynes, and are useful as active ingredients of pharmaceutical compositions for the prevention and treatment of cell proliferative disorders, in particular several forms of cancer.

Azonafide derivatives, methods for their production and pharmaceutical compositions therefrom

2&#x2033; oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2&#x2033; oxo-voruscharin compound or derivatives thereof. The disclosed 2&#x2033; oxo-voruscharin compound and its derivatives are useful for cancer treatment. Methods of treating cancer using the disclosed compounds are also disclosed.

Growing community of inventors

Woluwe-Saint-Lambert, Belgium

Eric Van Quaquebeke