Sanofi Sa

Sanofi

Eric Vallee

Jean-Pierre Maffrand

Daniel Frehel

Andre Bernat

Alain Badorc

Alain Bayol

Jean-Marie Pereillo

Jacqueline Lansen

Jean P Maffrand

Denis Delebassee

Denis Delabassee

N.alpha.-substituted derivatives of N.alpha.-arylsulphonylaminoacyl p-amidinophenylalaninamides, their preparation, their use as medicaments and intermediates for their synthesis.

Derivatives of the N

The present invention is concerned with compounds with the formula: ##STR1## in which: R.sub.1 represents a lower alkyl, a lower hydroxy alkyl or a benzyl group, a phenyl group or a 4-hydroxy phenyl group:

The present invention relates to novel derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno [3,2-c] 5-pyridyl) phenyl acetic acid corresponding to the following general formula: ##STR1## their addition salts with pharmaceutically-acceptable inorganic or organic acids as well as isomers and their mixtures. The invention also relates to their process of preparation and to medicaments containing these compounds which are of therapeutic use as inhibitors of platelet- and thrombotic-aggregation.

Derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro

This invention relates to new xylane sulfates having an apparent molar weight comprised between 7000 and 12000. This invention relates also to a process for their preparation by fractionation, and to the therapeutic application thereof as anti-thrombosis and hypolipemic agents.

Xylane sulfates, process for their preparation, and anti-thrombosis and

This invention relates to a new thieno-pyridinone derivative of the formula: ##STR1## and its pharmaceutically acceptable inorganic or organic acid addition salts. This invention relates also to a process for the preparation of said compound and to its therapeutic application as blood-platelet anti-aggregation agent and anti-thrombosis agent.

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Tournefeuille, France

Eric Vallee