Novasep Process

Novasep

Groupe Novasep

Novasep Equipment Solutions

Eric Valery

Marc-André Theoleyre

Stanislas Baudouin

Annick Merrien

David Laurent

Michel Bailly

Cédric Prieur

Philippe Adam

Wieslaw Majewski

Margit Holzer

Nicolas Pautal

Stéphane Oliveira

Hector Osuna Sanchez

Céline Morey

Jean Blehaut

Laurent David

The invention relates to a method for purifying a solution, the method comprising the following successive steps: &#x2014;bringing a solution to be purified into contact with an ion exchange resin by suspending the ion exchange resin in the solution to be purified, the ion exchange resin having the form of particles having a size Dv50 smaller than or equal to 200 &#x3bc;m; &#x2014;separating the solution into a purified solution and a loaded resin; &#x2014;regenerating the loaded resin by passing at least one regenerating solution through a compact bed of loaded resin. The invention also relates to an assembly for implementing the method.

Purification method using a low granulometry resin

The invention relates to a fluid distributor () for a column () comprising at least one cell () containing a bed of particles (), the fluid distributor () comprising: &#x2014;a floor () comprising at least one injection point () providing a fluidic connection on either side thereof; &#x2014;a layer of a resistive medium () fixed on one face of the floor (), the resistive medium being permeable to the fluid; &#x2014;a spacing device () inserted between the floor () and the layer of resistive medium () and maintaining a space for the circulation of the fluid between the floor () and the layer of resistive medium (). The invention also relates to a column, in particular a chromatography column, provided with this fluid distributor.

Fluid distribution unit for a chromatography column

The invention concerns a method for separating fractions of a mixture to be separated, in a device () comprising: several chromatography columns (,) mounted in series; an open separation loop comprising in input a point for injecting () eluent in one of the columns and in output a point for drawing () a fraction of the mixture. The method includes the following steps: batch injection of the mixture to be separated in the open separation loop (); collecting at least two fractions; offsetting at least one column of the eluent injecting and fraction drawing points () of the separation loop (). The invention also concerns a device for separating fractions of a mixture to be separated.

Method and device for separating fractions of a mixture

The invention relates to a method for separating fractions of a mixture to be separated including the steps of providing a device comprising at least two chromatography columns mounted in series, discontinuously injecting a mixture to be separated, in a single point of the device, discontinuously drawing off the fraction enriched in the product of interest, in a single point of the device, and injecting eluents in each column and displacing the points for injection eluents, the eluents having a different eluting power. The method allows efficient separation which is simple to perform.

Gradient-elution multi-column separation method

A process is disclosed for separating biomolecules from an aqueous solution containing the biomolectules and impurities, having different affinities and/or interactions with a solid support. The solution is passed over a fixed bed of chromatographic resin containing at least three zones, with flow of liquid being arranged between adjacent zones and between a last and first zone. Each of several sequences includes at least an adsorption stage, a rinsing stage, or a desorption stage, with each subsequent sequence being carried out by a downstream displacement of fronts in the zones by approximately the same increment before the periodical displacement of the introduction and withdrawal points.

Multicolumn sequential separation process

The invention concerns a method for separating fractions of a mixture using a chromatography device. The method includes the following steps: controlling in one node of the device, the history of a specific variable of the fractions of the mixture to be separated; detecting one characteristic point of the history, the characteristic point being between two successive steps of fraction collecting; comparing the position of the characteristic point relative to a target position; adjusting the amount of mobile phase modifying the position of the characteristic point to cause the position of the characteristic point to coincide with the target position. The invention also concerns a device for implementing the method. The method enables the operation of the device to be automatically set.

Process and device for separating fractions of a mixture

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Pulnoy, France

Eric Valery