Cardiac Pacemakers, Inc.

Ablative Solutions, Inc.

Topera, Inc.

Vasostitch, Inc.

Zipline Medical, Inc.

Stacyc, Inc.

The Johns Hopkins University

Oncosec Medical Incorporated

Rep Concepts, Inc.

Eric Thomas Johnson

Robert Ryan Ragland

Darrin James Kent

Jeff Alan Burke

Andy Edward Denison

Christopher Scott Hayden

David R Fischell

Tim A Fischell

Robert E Fischell

Phillip Charles Burke

Peter J D'Aquanni

Thomas F Kordis

Bruce Alan Tockman

Kent C B Stalker

Brian D Soltis

Amir Belson

Kevin Martin Magrini

Wade A Bowe

Ruchir Sehra

Bauback Safa

Eric Storne

Gary Hague

Gayla A Smith

Joelle Faulkner

Philip C Burke

Luke W Clauson

William Earl Webler, Jr

Paul E Zarembo

Christopher C Andrews

Anthony Nicolas Kalloo

John S Greenland

Neil M Becker

Scott A Stockmoe

Mouen A Khashab

Robert H Pierce

Jean Campbell

Arya Bahrami

Douglas W Brown

Richard J Connolly

Thomas L Kindberg

Gary L Hague

Luke Clauson

Robert Rayan Ragland

Kent Cb Stalker

A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a metallic tip for securably affixing the distal portions of the splines.

Basket style cardiac mapping catheter having a flexible electrode assembly for detection of cardiac rhythm disorders

An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.

Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures

An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Peri-vascular tissue ablation catheter with support structures

An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.

Peri-vascular tissue ablation catheters

An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Transvascular methods of treating extravascular tissue

A running bike that can be operated selectively with and without power. The running bike includes a front fork rotatably engaged with a front wheel, a rear fork rotatably engaged with a rear wheel, the rear fork having an upper portion and a lower portion, and a handlebar rotatably engaged with the front fork for steering the running bike. A frame extends between and connects the front fork and the rear fork. The frame includes a down tube having a first end connected to the front fork and a second end opposite the first end and positioned adjacent the rear fork, a top tube connected to and extending between the down tube and the upper portion of the rear fork, and a drivetrain receiving region defined as an area rearward of the down tube, forward of the rear wheel, and below the top tube.

Convertible motorized running cycle

The present disclosure provides a device and methods for acquiring tissue within a lumen or for closure of bodily openings.

Method and device for tissue acquisition or closure

An adaptive control method for controlling EP pulse parameters during electroporation (EP) of cells or tissue using an EP system includes providing a system for adaptive control to optimize EP pulse parameters including EP pulse parameters, applying voltage and current excitation signals to the cells, obtaining data from the current and voltage measurements, and processing the data to separate the desirable data from the undesirable data, extracting relevant features from the desirable data, applying at least a portion of the relevant features to a trained diagnostic model, estimating EP pulsing parameters based on an outcome of the applied relevant features, where the initialized EP pulsing parameters are based on the trained model and the relevant features, to optimize the EP pulsing parameters, and applying, by the generator, a first EP pulse based on the first pulsing parameters.

Systems and methods for improved tissue-sensing based electroporation

An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

A convertible running bike capable of selectively converting from a non-motorized configuration to a motorized configuration may include a front fork rotatably engaged with a front wheel, a handle bar rotatably engaged with the front fork for steering the bike, a frame and a seat connected to the frame.

An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, such as nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also controls the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Growing community of inventors

Temecula, CA, United States of America

Eric Thomas Johnson