L'oreal

Loreal Sa

Galderma Research & Development

Galderma Research & Development Snc

Eric Terranova

Alain Lagrange

Aziz Fadli

Thilo Fessmann

Jean-Claude Pascal

Jean-Michel Bernardon

Laurence Clary

Stéphane Sabelle

Michel Hocquaux

Jean Baptiste Galey

Jean R Maignan

Madeleine Leduc

Laurent Vidal

Jean-Baptiste Galey

Remy Tuloup

Khalid Bakkar

Sebastien Daver

V&eacute;ronique Birault

Christine Marty

Sébastien Daver

Vitamin D derivatives, notably non-steroidal vitamin D derivatives, are prepared from novel disubstituted phenylboronic acid compounds having the formula (I):  

Phenylboronic acid compounds and intermediates and processes for the preparation thereof

3-[5'-(3,4-bis(hydroxymethyl)benzyloxy)-2&#x2032;-ethyl-2-propylbiphenyl-4-yl]pentan-3-ol is prepared from the novel intermediate, 6-ethyl-4&#x2032;-(1-ethyl-1-hydroxypropyl)-2&#x2032;-propylbiphenyl-3-ol.

Preparation of 3-[5'-(3,4-bis(hydroxymethyl)benzyloxy)-2&#x2032;-ethyl-2-propylbiphenyl-4-yl]pentan-3-ol

A novel method for preparing 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid includes a Suzuki reaction between 3-adamantyl-4-methoxyphenylboronic acid of formula (II): and 6-bromo-2-naphthoic acid of formula (III): 

Method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid

Novel 7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds having the structural formula (I): are useful intermediates in the synthesis of non-steroidal derivatives of vitamin D.

7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds useful in the synthesis of non-steroidal analogues of vitamin D

The invention relates to novel diaminopyrazole having formula (I), wherein: R, R, identical or different, represent a CCmono- or polyhydroxyalkyl, isopropyl, n-propyl or ethyl group, said groups being linear or branched, and their physiologically acceptable salts. The invention also relates to a composition for dyeing keratinous fibres containing a compound having formula (I) and the method for using same. 

Diaminopyrazole compounds and the use thereof in the oxidation dyeing of keratinous fibres

Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPAR&#x3b3; receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for regulating and/or restoring skin lipid metabolism, for treating a wide variety of dermatological afflictions, and for preventing and/or treating the signs of aging and/or dry skin.

Biaromatic ligand activators of PPAR&#x3b3; receptors

The invention relates to novel diaminopyrazole compounds having formula (I): wherein Rrepresents a linear or branched C-Calkyl or n-propyl group, or a linear or branched C-Cmono or polyhydroxy alkyl group, and the addition salts thereof with a physiologically acceptable acid. The invention also relates to the compositions containing such a compound for the dyeing of keratinous fibres and the method for using said compositions.

The invention concerns novel diaminopyrazole derivatives of formula (I), wherein: Rrepresents C-Calkyl or C-C, preferably up to C, alkenyl, linear or branched, bearing at least a substituent selected among OR, NHR, NRR', SR, SOR, COOH, CONH, CONRR&#x2032;, PO(OH), SH, SOX, a non-cationic heterocycle, Cl, Br or I; X represents H, Na, K or NH; R and R&#x2032;, identical or different, represent C-Calkyl or C-C, preferably up to C, alkenyl, linear or branched, unsubstituted or substituted by one or several functional groups selected among OH, NH, OR, NHR, NRR&#x2032;, SR, SOR, SOR, COOH, CONH, CONRR&#x2032;, PO(OH), SH, SOX, a non-cationic heterocycle, Cl, Br or I, X, R and R&#x2032; having the definitions mentioned above; Rrepresents H, or C-Calkyl or C-C, preferably up to C, alkenyl, linear or branched, unsubstituted or substituted by one or several functional groups selected among OH, NH, OR, NHR, NRR&#x2032;, SR, SOR, SOR, COOH, CONH, CONRR&#x2032;, PO(OH), SH, SOX, a non-cationic heterocycle, Cl, Br or I, X, R and R&#x2032; having the definitions mentioned above; and their physiologically acceptable salts, and their use for oxidation dyeing of keratinous fibres, in particular human hair.

Diaminopyrazole derivatives and their use for oxidation dyeing of keratinous fibres

The subject of the invention is a composition for the oxidation dyeing of keratinous fibers, in particular human hair, comprising an oxidation base of the para-phenylenediamine type, substituted with a diazacycloheptane radical. The invention also relates to the method for dyeing fibers using this composition, and the novel compounds of the type mentioned above.

Composition for dyeing keratin fibers comprising at least one para-phenylenediamine substituted with a diazacycloheptane radical

The invention concerns novel dyeing compositions for keratinous fibers comprising at least a paraphenylenediamine derivative with pyrrolidinyl group as oxidation base, a dyeing method and a dyeing kit using said composition.

Dyeing compositions for keratinous fibers containing paraphenylenediamine derivatives with pyrrolidinyl group

The invention relates to diaminopyrazole derivatives having the following structure (I), wherein Rrepresents an alkyl or alkenyl radical bearing at least one substituent selected from among OR, NRR', SR, SOR, SOR, COOR, CONRR&#x2032;, PO(OH), SOX, NHCONRR, a non-cationic heterocycle, an aryl, a halogen. Rand Rare different from H and represent, independently of each other, an alkyl or alkenyl group; Rand R, together with the nitrogen atom to which they are attached, can form a heterocycle possibly comprising at least one other heteroatom selected from among N, O and S; Rand Ror the heterocycle that they form with the nitrogen to which they are attached can be substituted by at least one substituent defined above. The identical or different R, R&#x2032; groups are selected from a hydrogen atom, an alkyl or alkenyl group; R and R&#x2032;, together with the nitrogen atom to which they are attached, can form a heterocycle having at least 4 ring members that can contain at least one additional heteroatom selected from among O, N and S. X represents a hydrogen, an alkaline-earth or alkali metal atom or an ammonium group. The invention also relates to the dyeing compositions and the dyeing methods using same 

The invention concerns compounds derived from diaminopyrazole of formula (I), wherein: Ar is a 5- or 6-membered heteroaromatic radical capable of being condensed with one or several heteroaromatic cycles each comprising 5 or 6 members, and their physiologically acceptable addition salts with and acid. The invention also concerns compositions containing such a compound for oxidation dyeing of keratinous fibers and the method using said compositions 

Compounds derived from diaminopyrazole substituted by a heteroaromatic radical and their use in oxidation dyeing of keratinous fibers

The invention concerns compounds derived from diaminopyrazole of formula (I), wherein: Ris a linear or branched radical selected among C, C, Caminoalkyl radicals or C, C, Caminoalkenyl radicals, or one of the physiologically acceptable salts thereof. The invention also concerns compositions containing said compound for dyeing keratinous fibers and the method using said compositions.

Compounds derived from diaminopyrazoles substituted by an aminoalkyl or aminoalkenyl radical and their use in oxidation dyeing of keratinous fibres

The present, invention relates to novel 4,5-diaminopyrazole derivatives, to a composition for the oxidation dyeing of keratin fibers, and in particular of human keratin fibers, comprising, as oxidation base, at least one such derivative, and also to an oxidation dyeing process using this composition.

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Magagnosc, France

Eric Terranova