Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université Pierre Et Marie Curie (paris Vi)

Assistance Publique-hopitaux De Paris

Institut Curie

Institute Curie

Université De Paris

Université René Descartes Paris 5

Cytune Pharma

Université Paris Descartes

Institut Gustave Roussy

Universite Paris Cité

Université René Descartes (paris V)

Inserm

Eric Tartour

Ludger Johannes

David Bechard

Eric Deutsch

Bruno Goud

Allan M Green

Jean-Luc Perfettini

Wolf Herve Fridman

Alain Gey

Clémence Granier

Nadine Ben Hamouda

Nicolas Epaillard

Stéphane Oudard

Charles Dariane

Johannes Ludger

Mevyn Nizard

Thi Tran

Michèle Mondini

The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an immunomodulatory antibody or a fragment thereof directly or indirectly linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and a polypeptide comprising the amino acid sequence of the sushi domain of the IL-15R&#x3b1; or derivatives thereof; and uses thereof.

IL-15 and IL-15RAPLHA sushi domain based immunocytokines

The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein:

Universal carrier for targeting molecules to GB3 receptor expressing cells

Universal carrier for targeting molecules to Gb3 receptor expressing cells

The present invention relates to a composition comprising a) a B subunit of Shiga toxin or a functional equivalent thereof which is able to bind the Gb3 receptor, complexed with an antigen and b) at least one ligand of CDI capable of stimulating NK T cells; and to a pharmaceutical composition and a medicament comprising said composition.

Compositions comprising a B subunit of Shiga toxin and a means stimulating NKT cells

The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens.

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Paris, France

Eric Tartour