Lifecell Corporation

Eric Stec

Hui Xu

Li Ting Huang

Yi Heng Chen

Sean Collins

Rick T Owens

Nathaniel Bachrach

Ming F Pomerleau

Richard Seeman

The present application relates to use of transglutaminases to treat various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, and synthetics. The transglutaminases can be applied to the medical devices to provide advantages such as adhesion resistance or abrasion resistance.

Transglutaminase treated products

Tissue compositions and methods of preparation thereof are provided. The tissue compositions can be used to treat or regenerate muscle tissue. The compositions can be configured to provide increased strength compared to other muscle matrices.

Devices including muscle matrix and methods of production and use

The present application relates to use of transglutaminases to treat various tissue matrix products. The methods can include application of a transglutaminase to a partially denatured collagen-containing tissue matrix and implantation of the tissue matrix. The transglutaminase can facilitate adhesion with another collagen-containing tissue matrix, tissue surrounding the tissue matrix after implantation, or both.

Tissue matrix materials and enzymatic adhesives

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Washington, NJ, United States of America

Eric Stec