University of California

Eric Shifrut

Antoni Ribas

Alexander Marson

Theodore Lee Roth

Cristina Puig Saus

Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.

Targeted replacement of endogenous T cell receptors

Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-&#x3b2; chain and a heterologous TCR-&#x3b1; chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.

Growing community of inventors

San Francisco, CA, United States of America

Eric Shifrut