The Medical College of Wisconsin, Inc.

Imaging Biometrics, LLC

Prah, Douglas E.

Schmainda, Kathleen

Paulson, Eric S.

Eric S Paulson

X Allen Li

Ergun Ahunbay

Nikolai Mickevicius

Cun-geng Yang

Vern Hart

James Stewart Hyde

Andrzej Jesmanowicz

Andrew S Nencka

Kathleen M Schmainda

Lutfi Tugan Muftuler

Douglas Edward Prah

Daniel Shefchik

Douglas E Prah

Kathleen Schmainda

Systems and methods for providing image guidance for motion tracking and compensation in magnetic resonance imaging ('MRI') guided therapies, such as MRI-guided radiation therapies using an MR-linac or other MRI-guided radiation therapy system, are described. Simultaneous orthogonal plane imaging (“SOPI”) is used to acquire images from a first slice that remains static throughout the acquisition, and from a plurality of slices that are orthogonal to the first slice. This first slice can be referred to in some instances as a “tracking” or “navigator” slice, and the plurality of slices that are orthogonal to the first slice can be referred to as “imaging” slices. The tracking slice images can be used to estimate motion of the subject that occurred during the data acquisition, and to track the position of targets (e.g., anatomical targets) during the delivery of radiation treatment.

Method for real-time motion monitoring and dose accumulation in magnetic resonance guided therapies using simultaneous orthogonal plane imaging

Systems and methods for designing and fabricating three-dimensional objects with precisely computed material compositions for use in enhancing electromagnetic fields for magnetic resonance imaging ('MRI') are provided. As examples, the fabricated object can be designed to reduce magnetic field inhomogeneities in the main magnetic field of an MRI system, or to reduce inhomogeneities in a transmit radio frequency ('RF') field (i.e., a Bfield). As examples, the object can be a shim; a housing or other part of an RF coil; a medical device, such as a surgical implant; or component used in a medical device, such as a housing for an implantable medical device.

System and method for fabricating electromagnetic field enhancing objects for magnetic resonance imaging

Described here are systems and methods for providing three-dimensional motion estimates prior to and during MRI-guided therapies. In general, these systems and methods can include simultaneous orthogonal plane imaging ('SOPI'), synthetic volumetric imaging ('SVI'), self-navigated phase-resolved 4D MRI, radial CAIPIRINHA, and combinations thereof.

Systems and methods for motion management in magnetic resonance imaging guided therapies

Systems and methods directed to adaptive radiotherapy planning are provided. In some aspects, provided system and method include producing synthetic images from magnetic resonance data using relaxometry maps. The method includes applying corrections to the data and generating relaxometry maps therefrom. In other aspects, a method for adapting a radiotherapy plan is provided. The method includes determining an objective function based on dose gradients from an initial dose distribution, and generating an optimized plan based on updated images, using aperture morphing and gradient maintenance algorithms without need for organ-at-risk contouring. In yet other aspects, a method for obtaining 4D MR imaging using a temporal reshuffling of data acquired during normal breathing, a method for deformable image registration using a sequentially applied semi-physical model regularization method for multimodality images, and a method to generate 4D plans using an aperture morphing algorithm based on 4D CT or 4D MR imaging are provided.

Systems and methods for adaptive replanning based on multi-modality imaging

System and method for producing synthetic images

A magnetic resonance imaging (MRI) methodology is provided for simultaneous measurement of dynamic susceptibility contrast (DSC) MRI and dynamic contrast enhanced (DCE) MRI perfusion and permeability parameters using a combination of dual echo and spiral acquisition techniques with no contrast agent preload. T1 and T2/T2* leakage effects are eliminated, thereby permitting accurate measurement of blood volume, blood flow and vascular permeability which are used in evaluating tumor angiogenesis.

Multiparameter perfusion imaging with leakage correction

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Milwaukee, WI, United States of America

Eric S Paulson