Medtronic Ardian Luxembourg S.a.r.l.

Cibiem, Inc.

Ictero Medical, Inc.

Eric Ryba

Mark Gelfand

Denise Marie Zarins

Benjamin J Clark

Roman Turovskiy

Mark S Leung

Stephen Nash

Karun D Naga

Brian Kelly

Naomi Buckley

Danny Donovan

Luke Hughes

John Kelly

Fiachra Sweeney

Grace Kelly

Lana Woolley

Michael Cummins

Barry Mullins

Vincenzo Tilotta

Gary Kelly

Gwenda McMullin

Michael Turovskiy

Gwenda Francis

Gary P Kelly

Seamus Ledwith

Francesco Piccagli

Michael Mulanix

Aedan Mangan

David Waters

Matthew Nojoomi

Lana Wooley

Kovi Bessoff

Stephen Naash

Gwenda Mcmullin

Benjamni J Clark

Vicenzo Tilotta

Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

Neuromodulation cryotherapeutic devices and associated systems and methods

Provided herein are catheter devices, systems, and methods to ablate a tissue location. The devises, systems, and methods disclosed herein include ablation systems including a catheter system with inner and outer shafts that deliver an ablation medium (e.g., a cryogenic ablation medium) to a body lumen and evacuate the ablation medium from the body lumen. In some embodiments, devices, systems, and methods disclose herein include expandable structures that facilitate in positioning of nozzles and/or evacuation of ablation medium from a body lumen.

Systems, devices, and methods for ablation and defunctionalization of a gallbladder

Catheter apparatuses, systems, and methods for cryogenically modulating neural structures of the renal plexus by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a cryo-applicator to a renal artery via an intravascular path. Cryogenic renal neuromodulation may be achieved via application of cryogenic temperatures to modulate neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Cryoablation apparatuses, systems, and methods for renal neuromodulation

Methods and cryogenic devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation. Some methods include advancing a cryo-ablation catheter into a patient's vasculature and ablating tissue within a carotid septum.

Methods and devices for cryogenic carotid body ablation

Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment includes an elongated shaft and a cooling assembly at a distal portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site within or otherwise proximate a renal artery. The cryotherapeutic device can further include a supply lumen configured to carry liquid refrigerant toward the cooling assembly. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when in a deployed state.

Cryotherapeutic systems configured for refrigerant recompression and associated devices, systems, and methods are disclosed herein. A cryotherapeutic system configured in accordance with a particular embodiment includes a high-pressure line, a low-pressure line, a recompression unit, and a cryo-catheter. The recompression unit increases the pressure of refrigerant from the low-pressure line to the high-pressure line to a treatment pressure sufficient for cryogenic alteration of tissue. The high-pressure line and the low-pressure line include, respectively, a first connector and a second connector. The cryo-catheter includes a shaft, a supply lumen in the shaft that is coupled to the first connector, an exhaust lumen in the shaft that is coupled to the second connector, and a cryo-applicator attached to the shaft having a cooling chamber configured to receive refrigerant from the supply lumen and to return refrigerant via the exhaust lumen to the low-pressure line.

Refrigerant supply system for cryotherapy including refrigerant recompression and associated devices, systems, and methods

Growing community of inventors

Durango, CO, United States of America

Eric Ryba