Pfizer Corporation

Osi Pharmaceuticals, Inc.

Scios Inc.

Scios Nova, Inc.

Eric R Larson

Takushi Kaneko

Jotham Wadsworth Coe

Mark Carl Noe

Anton F Fliri

Thomas George Gant

Banavara L Mylari

James F Eggler

Robin J Andy

Philip Albert Carpino

Robert L Rosati

Kimberly O Cameron

James R Hauske

Todd W Siegel

Paul Da Silva-Jardine

The present invention relates to compounds of the formula 1 

Isothiazole derivatives useful as anticancer agents

The present invention relates to compounds of the formula 1  and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and to methods treating hyperproliferative disorders in mammals by administering the above compounds.

Benzothiophenes and related compounds as estrogen agonists

The present invention relates to compounds of the formula 1

Azacyclic-heterocyclic compounds as angiotension II receptor antagonists

Heterocyclic compounds for enhancing antitumor activity

Triazine derivatives for enhancing antitumor activity

Pyrimidine derivatives for enhancing antitumor activity

Human insulin analogs are disclosed. These analogs are tissue-selective. Accordingly, pharmaceutical formulations containing the analogs of the invention provide superior clinical benefits as compared to human insulin when used in the treatment of patients suffering from diabetes. The analogs are modified at amino residue A12, A15 or A19, are different from the naturally occurring residue at said position, and are hepatoselective. Also disclosed are human insulin analogs modified at amino acid residues A12 or A14 or amino acid residues A10 and A13 different from naturally occurring residues or residues at said position or positions and are peripheral selective. DNA sequences and microorganisms comprising sequences coding for human insulin analogs are also provided. Processes for preparing the human insulin analogs are described.

Method of treating diabetes with tissue-selective insulin analogs

Quinazolines derivatives for enhancing antitumor activity

Heterocyclic compounds as aldose reductase inhibitors

Tissue-selective insulin analogs

A method of using certain thiazolidine-2,4-diones in the treatment of hypertension.

Method for treating hypertension

Certain spirocyclic heterocyclic compounds, and their pharmaceutically-acceptable salts, are inhibitors of the aldose reductase enzyme, and so are useful for the control of diabetic complications. Exemplary compounds include compounds of the formula ##STR1## wherein Y is ##STR2## X is --O-- or ##STR3## R.sub.1 and R.sub.2 are each independently H, alkyl C.sub.1 -C.sub.6,aryl or arylalkyl (C.sub.1 -C.sub.6);

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Mystic, CT, United States of America

Eric R Larson