Allergan, Inc.

Alcresta Therapeutics, Inc.

Kobayashi Pharmaceutical Co., Ltd.

Other

Bayer Healthcare LLC

Eric R First

Ashish B Patel

James McCay

Atsushi Matsuo

David Widom

David K Brown

Jonathan Alexander Lee

Michiel Christian Alexander Van Vliet

Albert Archie Stone

Ryan Irvine

Guido Schmitz

Stephanie Petaway-Hickson

Hung-Huar Tong

Pradnya Beke

L Bruce Pearce

Karen E Kleiman

Shane E Durkee

Willem Robert Klass Schoevaart

Exemplary embodiments of the disclosure may be drawn to a device having an inlet and a chamber. Immobilized lipase, immobilized protease, and immobilized amylase may be contained within the chamber. The device may also include an outlet, wherein a flow path extends from the inlet, through the chamber, and to the outlet.

Devices and methods for the preparation of a nutritional formula

Exemplary embodiments of the disclosure may be drawn to ingestible delivery devices. An ingestible delivery device may include a first compartment and a second compartment. A lipase may be contained within the first compartment, and a fat may be contained within the second compartment. The first compartment may be sealed from the second compartment prior to exposure to a trigger, preventing the lipase and the fat from contacting each other, and at least one of the first compartment or the second compartment may at least partially rupture upon exposure to the trigger, allowing the lipase and the fat to contact each other.

Ingestible medical delivery devices

A tablet with an enhanced dissolution profile for a medicinally active ingredient such as aspirin and methods for making the tablet. The tablet comprises a blend of crystals of the medicinally active ingredient and a dissolution aid such as sodium or calcium carbonate or bicarbonate that coats the crystals upon co-milling. The blend is then compressed to form tablets that have an enhanced dissolution profile for the medicinally active ingredient.

Method and composition to improve absorption of therapeutic agents

Exemplary embodiments of the disclosure may be drawn to a device having a vessel configured to contain a source of lipids and a chamber fluidly connected to an outlet of the vessel. The chamber may contain immobilized lipase positioned within a flow path in the chamber along which the lipids flow when released from the vessel into the chamber. The device may also include an outlet through which the lipids flow after passing through the chamber.

Devices and methods for the supplementation of a nutritional formula

Methods for treating skin disorders by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a skin disorder.

Botulinum toxin therapy for skin disorders

Cosmetic compositions include a Clostridial neurotoxin component and a microsphere component. In certain compositions, the composition includes a botulinum toxin and a plurality of swellable microspheres. The compositions are administered to individuals, by injection and the like, to treat a cosmetic defect of deficiency.

Cosmetic neurotoxin compositions and methods

Methods for treating a pressure sore or for preventing development of a pressure sore by local administration of a Clostridial toxin, such as a botulinum neurotoxin, to a pressure sore or to a pressure point, or to the vicinity thereof.

Pressure sore treatment

Cosmetic compositions include a Clostridial neurotoxin component and a microsphere component. In certain compositions, the composition includes atoxin and a plurality of swellable microspheres. The compositions are administered to individuals, by injection and the like, to treat a cosmetic defect of deficiency.

Methods for treating melanin related afflictions by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a melanin related affliction.

Growing community of inventors

Boston, MA, United States of America

Eric R First