Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Eric Prinssen

Raffaello Masciadri

Roger David Norcross

Parichehr Malherbe

Sabine Kolczewski

Claus Riemer

Anja Limberg

Theodor Stoll

Daniela Brunner

Bavani G Shankar

Jessica Malberg

Hans Hilpert

Andrew William Thomas

Will Spooren

Pari Malherbe

The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formula (I) wherein Ar, X, X, R, R, R, m, n and the dotted line are as defined herein which compounds are useful for treating certain central nervous system disorders as described herein.

Indolin-2-one or pyrrolo-pyridin/pyrimidin-2-one derivatives

The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formula wherein is phenyl or a heteroaryl group, selected from pyridinyl, pyrimidinyl, imidazolyl, isoxazolyl or pyrazolyl; is phenyl or pyridinyl, wherein the N atom in the pyridinyl group may be on all free positions;

2-oxo-2,3-dihydro-indoles for the treatment of CNS disorders

The present invention relates to compounds of formula I wherein R, Rand Rare as defined in the specification, which are active at the GABAreceptor and which can be used for the treatment of CNS disorders.

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The present invention a method of treating anxiety by administering compounds that are active on the GABAreceptor, having formula I: wherein R, R, R, R, Rand Rare as defined in the specification and claims.

2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives

The present invention relates to compounds of formula I: wherein R, R, R, R, Rand Rare as defined in the specification and claims, which compounds are active on the GABAreceptor and are useful in the control or prevention of CNS illnesses, especially of illnesses and disorders comprising anxiety, depression, epilepsy, schizophrenia, and cognitive disorders.

The present invention relates to compounds of formula wherein It has been found that the compounds of the invention are active on the GABAreceptor and therefore are useful for the treatment of anxiety, depression, epilepsy, schizophrenia, cognitive disorders, spasticity and skeletal muscle rigidity, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and craving associated with cocaine and nicotine, psychosis, panic disorder, posttraumatic stress disorders and gastro-intestinal disorders.

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Guebwiller, France

Eric Prinssen