Bausch-Lomb Incorporated

Eric Phillips

Mohannad Shawer

Martin J Coffey

Joseph C Salamone

Jay Friedrich Kunzler

Alok Kumar Awasthi

Susan E Burke

Vicki Barniak

Hongna Wang

Fang Zhao

Harry M King, Jr

Paramita Bandyopadhyay

Zora Teresa Marlowe

A suspension includes an ophthalmic active ingredient suspended in a formulation vehicle including a suspending agent and a non-ionic cellulose derivative. The ophthalmic active agent is present as particles having D&#x3c;5 &#x3bc;m and D&#x3c;1 &#x3bc;m. The suspension may be administered to a patient for treating an ophthalmic inflammatory condition.

Ophthalmic suspension composition

Amorphous solid-state form of (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-1H-azepin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid is characterized by at least one of: (a) an X-ray powder diffraction ('XRPD') spectrum that comprises peaks at 2&#x3b8; angles of 6.9-7.1, 9.4, 10.6-10.7, and 13.4-13.7&#xb0;&#xb1;0.2&#xb0;, and a diffuse halo pattern at 11-30&#xb0;; and (b) a DSC (differential scanning calorimetry) melting peak at about 267-272&#xb0; C. The amorphous solid is prepared by rapid precipitation from a saturated or supersaturated solution of besifloxacin free base in a solvent comprising at least benzyl alcohol.

Amorphous besifloxacin solid

A topical pharmaceutical composition comprising a pharmaceutical active and a polymer of general formula I or general formula II 

Polymeric quaternium compounds

An aqueous ophthalmic composition comprising a branched, glycerol monoalkyl compound and a fatty acid monoester. The fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion. The composition will also have an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg. The invention is also directed to a method of inhibiting the formation of foam in an aqueous ophthalmic composition that includes a surfactant as well as to a method of enhancing the biocidal efficacy of an aqueous ophthalmic composition containing a fatty acid monoester.

Ophthalmic compositions comprising a branched, glycerol monoalkyl compound and a fatty acid monoester

Growing community of inventors

Ontario, NY, United States of America

Eric Phillips