Xerox Corporation

Palo Alto Research Center Inc.

Verily Life Sciences LLC

Google Inc.

X Development LLC

Palo Alto Research Corporation Incorporated

Other

Wing Aviation LLC

Verify Life Sciences LLC

Palo Alto Research Institute Incorporated

Eric Peeters

Joel A Kubby

Eric Teller

Armin R Volkel

Christopher L Chua

Scott Albert Uhland

Meng H Lean

David Kalman Biegelsen

Raj B Apte

Decai Sun

David Kirtland Fork

Warren Bruce Jackson

Ashish V Pattekar

Richard H Bruce

Eugene Michael Chow

Patrick Yasuo Maeda

Scott Alan Elrod

Dan A Hays

Karen Ann Moffat

Francisco Eduardo Torres

Timothy D Stowe

Jeng Ping Lu

Johnny Hsienchow Lee

R Enrique Viturro

Peter Michael Kazmaier

Fred F Hubble, Iii

Stanley John Wallace

Richard P N Veregin

Linda T Romano

Daniel Gureasko Bobrow

Maria N V McDougall

Michael L Chabinyc

Robert Anthony Street

Thomas L Paoli

Chu-Heng Liu

Naveen Chopra

David Allen Mantell

Peter Gordon Odell

Robert Arthur Sprague

Noble Marshall Johnson

Andrew A Berlin

T Brian McAneney

Robert L Thornton

Marc E Mosko

James R Larson

Philip D Floyd

Jaan Noolandi

William Graham Patrick

Gregory B Anderson

Michel A Rosa

Benjamin David Krasnow

Peter H Smith

Ross D Bringans

Andrew J Conrad

Alan G Bell

Koenraad F Van Schuylenbergh

Gregory J Kovacs

Jason Donald Thompson

Steven B Bolte

Donald Leonard Smith

Vikram Singh Bajaj

Philipp Helmut Schmaelzle

Francesco Lemmi

Tuan Anh Vo

Ramkumar Abhishek

Alan J Werner, Jr

Armin Rainer Völkel

Bryan Thomas Preas

Thomas Hantschel

Peter Massaro

Kaiser H Wong

Maria N McDougall

John Stuart Fitch

Huangpin Ben Hsieh

James F O'Neill

Victor Marcel Acosta

Tiantian Zha

Alex T Tran

David Mathew Johnson

Jurgen Hans Daniel

Steven E Ready

Joerg Martini

Dirk De Bruyker

Danielle C Boils

Lars-Erik Swartz

Martin Sheridan

G A Connell

Eric Saund

Frank C Genovese

Stephen F Pond

Brett Daniel Schleicher

Ana Claudia Arias

Andrew Homyk

Serena H Wong

Sergey Brin

John E Northrup

Christopher A Paulson

Scott Eugene Solberg

Constance J Thornton

Jackson H Ho

Described herein are systems and methods of collecting, processing, and analyzing breath exhaled from a subject. Specifically, described herein are systems and methods for minimizing the amount of breath needed for analysis. Further disclosed herein are systems and methods to analyze compounds contained in a subject's breath that are indicative of certain ailments and/or present in a low concentration in the subject's breath. The systems can include a reaction chamber, a breath inlet, a reactant inlet, a fluid atomizer, and a receiving substrate for analyzing the process subject's breath. The methods can include reacting a subject's breath with a reactant to analyze the contents of the subject's breath.

Systems and methods for analyzing exhaled breath

An insect separating apparatus may include a sensor positioned to detect one or more insects when present within a test chamber. For example, the sensor may emit signals into the test chamber and receive reflected signals indicative of Doppler shifts caused by movement of the one or more insects. Based on information from the sensor, a computing device may determine a characteristic of the one or more insects in the chamber, such as a wing beat frequency, sex, or other characteristic. The computing device may instruct different responses based on the characteristic determined, such as activating an air mover to divert detected mosquitos out of the test chamber in response to the determined characteristics matching those of female mosquitos, or deactivating or maintaining the air mover in an inactive condition in response to the determined characteristics matching those of male mosquitos, for example, to allow passage through the chamber into a collection receptacle.

Automated flying insect separator

A method for real-time, high-density physiological data collection includes automatically measuring, by a wearable device, one or more physiological parameters during each of a plurality of measurement periods, and upon conclusion of a measurement period, for each of the plurality of measurement periods, automatically transmitting by the wearable device data representative of the physiological parameters measured during that measurement period, to a server, the server configured to develop a baseline profile based on the data transmitted by the wearable device for the plurality of measurement periods. The measurement periods may extend through a plurality of consecutive days, and each of the consecutive days may include multiple measurement periods. At least some of the physiological parameters are measured by non-invasively detecting one or more analytes in blood circulating in subsurface vasculature proximate to the wearable device.

Physiological measurement using wearable device

A method for modulating a response signal includes introducing functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles are configured to interact with one or more target analytes present in blood circulating in the subsurface vasculature; and non-invasively detecting the one or more target analytes. A response signal, which may include a background signal and an analyte response signal related to interaction of the functionalized particles with the one or more target analytes, is transmitted from the subsurface vasculature. A modulation configured to alter the response signal such that the analyte response signal is affected differently than the background signal may be applied to a portion of subsurface vasculature. Analyte detection may be achieved by differentiating the analyte response signal from the background signal.

Modulation of a response signal to distinguish between analyte and background signals

An ultrasound device, including (i) an ultrasound transducer, and (ii) a coupling material in contact with the ultrasound transducer is presented. The coupling material can comprise a solid component and a liquid component, wherein the liquid component is absorbed within the solid component and forms a microscopic liquid layer on a surface of the solid component, through which acoustic energy from the ultrasound transducer can be conducted. The device can be mounted to an external body surface proximate to a portion of the lumen, allowing the device to measure the rate at which a component moves through the lumen. Also provided are methods for making the device and using the device to determine a physiological parameter based on at least the flow rate of a component through the lumen.

Energy coupling material for wearable ultrasound devices

Devices are provided to automatically access blood from beneath or within skin. These devices include a plurality of injectors configured to drive needles into the skin and draw samples of blood into the device. These devices additionally include a plurality of sensors which can detect a target analyte in the blood samples received by the device. These devices further include a user interface, which may prompt the user to self-administer a dose of a substance, or accept a user input which could affect or otherwise influence the activation of the device (i.e., the firing of needles to draw blood samples into the device and detect an analyte). These devices can be wearable and configured to automatically access blood from skin, for example, to access blood from the skin at one or more points in time after the user has self-administered a dose of a substance.

Apparatus for automated glucose tolerance testing

Devices for micro-fluid mixing micro-fluids are presented, together with example methods for micro-mixing using example devices. An example device may include a micro-volume fluid chamber (&#x3bc;VFC), a micro-volume mixing chamber (&#x3bc;VMC), and a source of a target micro fluid. The &#x3bc;VFC may include two slidably-mounted piston segments that divide the &#x3bc;VFC into three sub-volumes, one of which initially contains a mixer micro-fluid. The source of the target micro fluid may be triggered to deliver the target micro-fluid into another of the sub-volumes via an inlet channel. A propellant may be triggered to drive axial motion of the piston segments, causing the sub-volumes to compress. Through this action, the mixer micro-fluid may be expelled via a first outlet channel into the &#x3bc;VMC, and the target micro-fluid may be expelled via a second outlet channel into the &#x3bc;VMC. As the piston segments move, they block and unblock the inlet and outlet channels.

System and method for metering, dispensing, filtering, and mixing micro-volumes of fluids

An intragastric balloon device including a deformable material is in an ingestible form for delivery to a stomach of a patient, expands in response to stimuli in the stomach, and degrades within a limited duration (such as 16 hours or some other value between 2 hours and 72 hours) to diminish to passable form in which remains of the intragastric balloon device are passable from the stomach. In an illustrative example, the deformable material is composed of silicone coated with parylene and encloses perfluoropentane fluid that transitions from liquid to gas due to stomach temperature to inflate the balloon in the stomach and occupy space in the stomach until a fuse of methacrylate erodes to unblock a vent conduit to permit escape of the perfluoropentane for deflating the balloon to diminish to passable form.

Ingestible intragastric balloon

A system for needle-free drawing of blood is disclosed. A hand-portable device can include an evacuated negative-pressure barrel with a membrane sealing an aperture at a distal end, and a housing affixed to a proximal end. An accelerator barrel can be positioned within the negative-pressure barrel and fixed to the housing, with an open proximal end in a chamber in the housing, and an open distal end aligned with the aperture. The chamber can be filled with pressurized gas, and a trigger valve can hydrostatically separate the chamber from the open proximal end of the accelerator barrel. A micro-particle positioned within the accelerator barrel can be accelerated to high speed by an abrupt surge of gas by releasing the trigger valve. The micro-particle can attain enough momentum to pierce the aperture membrane and penetrate adjacent dermal tissue. A resulting micro-emergence of blood can be drawn into the negative pressure barrel.

Needle-free blood draw

Devices are provided to automatically inject drugs or other payloads into or beneath skin. These devices include an injector configured to drive a hollow needle into the skin and subsequently to deliver the payload through the hollow needle. Applied suction acts to draw blood from the puncture formed in the skin through the hollow needle, into the device, and to a sensor, blood storage element, or other payload. In some examples, the blood is drawn through the hollow needle when the hollow needle is penetrating the skin. In some examples, these devices are additionally configured to retract the hollow needle from the skin and/or to perform some other functions. These devices can be wearable and configured to automatically access blood or deliver a payload into skin, for example, to operate at one or more points in time while a wearer of a device is sleeping.

Automated sequential injection and blood draw

The present disclosure relates to systems and methods for low-power, data transmission using ultrasound signals. In one implementation, a data transmission system includes an ultrasound transducer configured to generate ultrasound signals in response to power supplied from a power source, and a mechanical ultrasound amplifier coupled to the ultrasound transducer, the ultrasound amplifier having a substrate adapted to function as a soundboard to amplify the ultrasound signals. The range of the data transmission system may be increased with a relay system. The relay system may include one or more detectors and one or more repeaters.

Ultrasound communications for low-power biosensor applications

A wearable device includes a detector configured to detect a response signal transmitted from a portion of subsurface vasculature, the response signal being related to binding of a clinically-relevant analyte to functionalized particles present in a lumen of the subsurface vasculature. Program instructions stored in a computer readable medium of the device, and executable by a processor, may cause the device to determine a concentration of the clinically-relevant analyte based on the response signal detected by the detector; determine whether a medical condition is indicated based on at least the concentration of the clinically-relevant analyte; and, in response to a determination that the medical condition is indicated, transmit data representative of the medical condition via the communication interface. The device may also include a signal source configured to transmit an interrogating signal into the portion of subsurface vasculature, thereby generating a response signal in response to the interrogating signal.

Devices and methods are provided for transmucosal drug delivery. The transmucosal drug delivery device may include a housing configured for intralumenal deployment, such as intravaginally, into a human or animal subject; a drug-dispensing portion which contains at least one drug, the drug-dispensing portion being configured to dispense the drug from the housing by positive displacement; and a permeability enhancer-dispensing portion configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance.

Transmucosal drug delivery device and method including chemical permeation enhancers

Compact devices are provided to measure hematocrit of a blood sample. These devices include first and second chambers that receive respective portions of a blood sample via respective filters. The material of the filters prevents passage of red blood cells while permitting passage of blood plasma. One of the filters has one or more holes to permit the passage of whole blood. Thus, when an example device is presented with a sample of blood, one of the chambers contains whole blood and the other contains blood from which the red blood cells have been filtered. Electrodes in each of the chambers can then be used to detect the impedances of the whole blood and the filtered blood, and the detected impedances can be used to determine a hematocrit of the sample of blood.

Compact blood hematocrit sensing device

Growing community of inventors

Mountain View, CA, United States of America

Eric Peeters