Case Western Reserve University

The Penn State Research Foundation

Eric Pearlman

Sixto M Leal, Jr

Mark Kester

A method of treating a fungal infection in a subject includes topically administering to the subject a therapeutically effective amount of a fungal iron acquisition inhibitor to treat fungal infection in the subject.

Fungal iron acquisition inhibitors and uses thereof

A method for treating and preventing diseases associated with neutrophil infiltration, particularly ocular diseases, is provided, which method comprises administering to a subject in need thereof an effective amount of ceramide or a derivative thereof. Also provided is a composition for treating diseases associated with neutrophil infiltration, the composition comprising ceramide or a derivative thereof.

Ceramide composition and method of use

A method of inhibiting IL-17 expression in neutrophils of a subject in need thereof includes administering to neutrophils of the subject a therapeutically effective amount of agent that inhibits STAT3 mediated IL-17 expression in the neutrophils of the subject.

Compositions and methods of inhibiting IL-17 expression of neutrophils

A method of treating a fungal infection in a subject including administering to the subject a therapeutically effective amount of a thioredoxin protein inhibitor to treat the fungal infection in the subject.

Thioredoxin protein inhibitors and uses thereof

A method of treating corneal inflammation in a subject includes administering to the subject a therapeutically effective amount of a TLR4 antagonist.

Growing community of inventors

Cleveland, OH, United States of America

Eric Pearlman