University of California

Arizona Board of Regents on Behalf of the University of Arizona

Eric Olaf Potma

Bruce J Tromberg

Rongguang Liang

Zhongping Chen

Hideharu Mikami

Gangjun Liu

Dan M Cooper

Mihaela Balu

Kim Lu

Mihael Balu

Adam Hanninen

A reflective microscope objective lens includes a concave mirror system that reflects incoming radiation, a convex mirror in optical communication with the concave mirror system, and a primary concave mirror in optical communication with the convex mirror. The concave mirror system includes a first concave mirror. The primary concave mirror focuses outgoing radiation onto a focal plane wherein the concave mirror system. Characteristically, the convex mirror and the primary concave mirror are arranged to direct light along a non-concentric path.

Reflective microscope objective lens for all colors

The technology relates to devices and methods thereof for the detection of one or more biomarkers from a user's exhaled breath. In one embodiment, the present invention provides a device comprising a metered dose inhaler, and a sensor that detects one or more biomarkers comprising HFA, CO, and NO. In another embodiment, the device detects HFA, COand NO simultaneously by photoacoustic spectroscopy. In another embodiment, the device may be used as part of an overall treatment regimen for asthma or COPD.

Detection of biomarkers from exhaled breath

A multiphoton microscope based on two-photon excited fluorescence and second-harmonic generation that images FOVs of about 0.8 mm(without stitching adjacent FOVs) at speeds of 10 frames/second (800&#xd7;800 pixels) with lateral and axial resolutions of 0.5 &#x3bc;m and 2.5 &#x3bc;m, respectively. The scan head of the instrument includes a fast galvanometric scanner, relay optics, a beam expander and a high NA objective lens. The system is based on a 25&#xd7;, 1.05 NA water immersion lens, which features a long working distance of 1 mm. A proper tailoring of the beam expander, which consists of the scan and tube lens elements, enables scaling of the FOV. The system and method also include a flat wavefront of the beam, minimum field curvature, and suppressed spherical aberrations. All aberrations in focus are below the Marechal criterion of 0.07&#x3bb; rms for diffraction-limited performance.

Imaging platform based on nonlinear optical microscopy for rapid scanning large areas of tissue

A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging.

System and method for efficient coherence anti-stokes raman scattering endoscopic and intravascular imaging and multimodal imaging

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Irvine, CA, United States of America

Eric Olaf Potma