Alza Corporation

Henkel Ag & Company, Kgaa

Henkel IP Holding Gmbh

National Starch and Chemical Investment Holding Corporaton

Eric N Silverberg

Paul B Foreman

Allison Luciano

Robert M Gale

Jianye Wen

Jay Douglas Audett

Eli J Goldman

Michel J N Cormier

Rama V Padmanabhan

Jay Audette

John Gregory Woods

Andrew D Messana

Michael Timothy Philbin

Rama S Chandran

Smita M Shah

Laxmisha Sridhar

Sean M Burdzy

Peter A Walter

Bruce Stevens

Young Taek Choi

The present disclosure is directed to random, acrylic co-polymers that are useful in transdermal applications. Methods of making and using the described co-polymers are also described.

Acrylic polymers and their use in transdermal drug delivery

Disclosed are photoinitiators that are ultra violet (UV) reactive. The photoinitiators can be polymerized into polymeric backbones for use in UV curable hot melt pressure sensitive adhesives. The preferred polymeric backbones are acrylic-based polymers. The photoinitiators are very UVC sensitive and have excellent hot melt viscosity stability that is many fold higher than existing photoinitiators. The subject photoinitiators feature aryl ketones linked through an ether linkage to a variety of connector sequences that allow for polymerization of the photoinitiators.

Photoinitiators that are polymeric or polymerizable for use in UV curable pressure sensitive adhesives

A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.

Transdermal nicotine salt delivery system

A polyacrylate formulation suitable for delivery of drug to through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.

High enhancer-loading polyacrylate formulation for transdermal applications

An adhesive composition which lacks functional groups containing reactive hydrogen moieties and contains no post-polymerization chemical crosslinker finds use in transdermal drug delivery systems. The invention enables the administration of drugs containing a reactive functional group, which drugs have heretofore not been able to be administered by the transdermal route using conventional acrylic adhesives.

Non-reactive adhesive useful in transdermal drug delivery system

Method of making a high enhancer-loading polyacrylate formulation for transdermal applications

A polyacrylate formulation suitable for delivery of drug through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.

Acrylic polymers comprising vinyl acetate monomers, hydroxyl functional monomers and low Tg alkyl acrylate monomers are useful in adhesive compositions that find use in skin contact applications.

Acrylic polymer-based adhesives

Acrylic polymers comprising a non-primary hydroxyl functional monomer and low Tg alkyl acrylate monomers are useful in adhesive compositions that find use in skin contact applications.

Pressure sensitive adhesive formulations comprising an acrylic copolymer and a mixture of tackifiers exhibit outstanding adhesion to foam facestocks.

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Summit, NJ, United States of America

Eric N Silverberg