Boehringer Ingelheim International Gmbh

Boehringer Ingelheim (canada) Ltd.

Boehringer Ingelheim Pharma Gmbh & Co Kg

Christiane Yoakim

William W. Ogilvie

Robert Deziel

Eric Malenfant

Bounkham Thavonekham

Jeffrey O'Meara

William W Ogilvie

Youla S Tsantrizos

Bruno Simoneau

Martin Duplessis

Teddy Halmos

Clint A James

Claudio F Sturino

Anne-Marie Faucher

Christian Brochu

Paul John Edwards

Serge R Landry

Sebastien Morin

Robert D&eacute;ziel

Patrick Deroy

Julie Naud

Jean-Eric Lacoste

Marc Pesant

Martin Tremblay

Louis Morency

Michael C Boes

Robert Déziel

Joannie Minville

Ingrid Guse

Stephen Mason

Craig Fenwick

Jean-Marie Ferland

Claudio Sturino

Paul J Edwards

Michael Boes

Compounds of formula (I): wherein R, R, A, A, A, A, X and Y are as defined herein, are useful as inhibitors of HIV replication.

Inhibitors of HIV replication

Compounds of formula I: wherein a, b, c, X, R, R, R, Rand Rare defined herein, are useful as inhibitors of HIV replication.

Inhibitors of human immunodeficiency virus replication

Compounds represented by formula I: wherein Ris H, halogen, (C)alkyl, O(C)alkyl, and haloalkyl; Ris H or (C)alkyl; Ris H or (C)alkyl; Ris (C)alkyl, (C)alkyl(C)cycloalkyl, or (C)cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C)alkyl which in turn maybe optionally substituted with pyridinyl-N-oxide or C(O)OR wherein R is H or (C)alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.

Non-nucleoside reverse transcriptase inhibitors

Azetidinone derivatives for the treatment of HCMV infections

Disclosed herein is a process for preparing (S)-.alpha.-amino-1-carboxycyclopentaneacetic acid which is a useful intermediate for preparing peptidomimetic inhibitors of herpes viral ribonucleotide reductase. The process comprises the preparation of the key intermediate ##STR1## and its subsequent conversion to the desired product.

Process and intermediates for

Growing community of inventors

Laval, Canada

Eric Malenfant