I-flow Corporation Inc.

Confluent Medical Technologies, Inc.

Interface Associates, Inc.

Avent, Inc.

Eric Mabry

Kenneth Wayne Rake

Josef J Stupecky

Roger Dillard Massengale

Matthew F Tonge

Kevin Justin Herrera

Don Ngo-Chu

A nested balloon is provided where each balloon is formed from tubing that optimizes the inner wall stretch thus providing maximum balloon strength. The high pressure, nested balloon is provided with layers that allow for slipping, such that the balloon has a very high pressure rating and toughness, yet excellent folding characteristics. Methods for producing such nested balloons using existing balloon forming equipment are also provided. The nested balloons can have layers with low-friction surfaces. The nested balloons are preferably manufactured using a variety of methods, including pressurized constrained annealing.

Methods of manufacturing nested balloons utilizing pressurized constrained annealing

A multi-layered balloon is provided where each layer is formed such that each layer is made from tubing that optimizes the inner wall stretch thus providing maximum balloon strength. The high pressure, multi-layer balloon is provided with layers that allow for slipping, such that the balloon has a very high pressure rating and toughness, yet excellent folding characteristics. Methods for producing such multi-layer balloons using existing balloon forming equipment are also provided. The multi-layer balloons can have alternating structural and lubricating layers, or layers with low-friction surfaces. The multi-layer balloons are preferably manufactured using a variety of methods including nesting, co-extrusion, or a combination of nesting and co-extrusion. The multi-layer balloons have balloon layers having substantially similar, or the same, high degree of biaxial orientation of their polymer molecules such that each balloon layer of the multi-layer balloon will fail at approximately the same applied pressure.

Methods for manufacturing multi-layer balloons for medical applications

Multi-layer balloons for medical applications and methods for manufacturing the same

A device and method for the infusion of medicinal fluid at a controlled flow rate to a wound site or the blood stream of a patient is disclosed. A pump delivers fluid under pressure from a fluid source through a continuous and substantially constant flow path and through a supplemental bolus dose flow path. A large volume bolus dose reservoir accumulates a large quantity of fluid from the bolus dose flow path and holds the fluid under pressure. A flow regulator controls the fill rate of the large volume bolus reservoir. The large volume supplemental bolus dose is released from the bolus reservoir upon patient activation of a valve. The release rate of the bolus dose is controlled by the decompression of an elastomeric sphere or spring chamber, by the pressure gradient at the valve and/or by optional flow control tubing. In one embodiment, a source of fluid under pressure is pumped at a continuous and substantially constant rate to a wound site or the blood stream of a patient and into a bolus syringe, which is capable of holding a large quantity of fluid under pressure. A plunger on the bolus syringe may be depressed to release a bolus dose of fluid into a chamber accumulator and then to the patient at a controlled release rate.

Large volume bolus device and method

A device for regulating the flow rate of a fluid includes a housing containing a plurality of flow conduits fluidly connecting an inlet and an outlets each of the flow conduits comprising a flow control tube and a resiliently compressive occlusion tube, wherein the flow control tubes are of substantially equal internal diameter. Each of the flow control tubes has a length associated with a different flow rate. A resilient flow-blocking element is operatively associated with each of the occlusion tubes and is movable into a flow-blocking compression against its associated occlusion tube. An actuation mechanism in the housing is operable (a) to selectively engage and move one or more of the flow-blocking elements into the flow-blocking compression against its associated occlusion tube, and (b) to selectively be disengaged from any of the flow-blocking elements.

Device for selectively regulating the flow rate of a fluid

A device for regulating the flow rate of a fluid includes a housing containing a plurality of flow conduits fluidly connecting an inlet and an outlet, each of the flow conduits comprising a flow control tube () and a resiliently compressive occlusion tube (), wherein the flow control tubes are of substantially equal internal diameter. Each of the flow control tubes has a length associated with a different flow rate. A resilient flow-blocking element () is operatively associated with each of the occlusion tubes and is movable into a flow-blocking compression against its associated occlusion tube. An actuation mechanism () in the housing is operable: (a) to selectively engage and move one or more of the flow-blocking elements into the flow-blocking compression against its associated occlusion tube, and (b) to selectively be disengaged from any of the flow-blocking elements.

A patient controlled liquid drug administration device comprises a reciprocating pump having an inlet connectable to a source of a pressurized liquid drug, and an outlet connectable to the patient. A clamp rotates between closed and open positions respectively blocking and enabling pump outflow. A plunger above the pump has an end contacting a movable wall of the pump and is movable between raised and lowered positions. A button above the plunger moves between extended and depressed positions, and has a ledge that engages the clamp when the button is moved to the depressed position and moves the clamp to its open position. A compression spring is disposed between the plunger and the button. A spring catch engages a detent in the button when the button is moved to its depressed position and holds the button there until released by a catch release on the plunger that disengages the spring catch from the detent in the button when the plunger is moved to its lowered position. A removable tab permits easy, rapid priming of the pump by holding the clamp in its open position regardless of the position of the button, and by holding the button in its depressed position regardless of the position of the plunger.

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Trabuco Canyon, CA, United States of America

Eric Mabry