Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

Eric M Pridgen

Robert Samuel Langer

Omid C Farokhzad

Stephen J Lippard

Rohit Nandkumar Karnik

Pedro M Valencia

Suresh Gadde

Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a Pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the Pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. Also provided are methods of making these nanoparticles.

Nanoparticles for targeted delivery of multiple therapeutic agents and methods of use

Growing community of inventors

Boston, MA, United States of America

Eric M Pridgen