Mayo Foundation for Medical Education and Research

Eric M Poeschla

Roman A Barraza

Moses Rodriguez

Arthur E Warrington

Allan J Bieber

Meghan McGee Painter

This document provides methods and materials related to treating glaucoma, ocular hypertension, cardiovascular diseases, and renal diseases. For example, this document provides isolated nucleic acid molecules and viral vectors (e.g., lentiviral vectors) containing isolated nucleic acid molecules. Methods for reducing intraocular pressure as well as symptoms and progression of cardiovascular and renal diseases also are provided.

Treating glaucoma, cardiovascular diseases, and renal diseases

This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods and materials for reducing the severity of a viral infection present in a mammal (e.g., a human) are provided.

Methods and materials for reducing the severity of viral infections

This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods for increasing expression of an Oas gene family polypeptide, an Ifit gene family polypeptide, an Isg15 polypeptide, a Rig-1 polypeptide, a Mda5 polypeptide, and a Mx1 polypeptide in mammals using a lentiviral vector comprising nucleic acid encoding a picornavirus 3Dpol polypeptide (or a fragment thereof) are provided.

Growing community of inventors

Rochester, MN, United States of America

Eric M Poeschla