Lxn Corporation

Diabetes Diagnostics, Inc.

Eric M Nelson

Todd C White

Matthew A Coe

A method and apparatus for controlling the absorption of a liquid sample through an absorbent layer ( ) and reducing the effect of hematocrit by applying the sample on one side of the layer ( ) and providing an air gap ( ) on the opposite side, so that absorption is controlled by preventing the release of air from the air gap.

Air gap for controlling sample absorption and hematocrit dependence

The present invention provides a method of sonic treatment to selectively reduce the void volume of a sintered polymer such as porous high density polyethylene (HDPE). The invention also provides a method and an article of manufacture for receiving a liquid sample, where a first portion of the sintered polymer (1a) overlies a solid surface (4a) and a second portion of the polymer (1b) overlies a window (4b). Sonic treatment of the sintered polymer reduces the void volume of the first portion (1a) compared to the second portion (1b). As a result, a liquid sample applied to the polymer will preferentially migrate through the second portion (1b), rather than through the first portion (1a). When the article of manufacture is used to analyze a liquid sample such as blood, less sample is required because of the preferential migration in the sonically treated sintered polymer.

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San Clemente, CA, United States of America

Eric M Nelson