The Ohio State University

University of California

The University of North Carolina at Chapel Hill

Cardinal Health 414, LLC

Eric M Bachelder

Abhay R Satoskar

Jean M J Frechet

James Fuchs

Li Pan

Alan Douglas Kinghorn

Tristan T Beaudette

Kristy Ainslie

Kyle E Broaders

Jenny P-y Ting

Larry Schlesinger

Michael Andrew Collier

Brandon Johnson

Frederick O Cope

Narasimham L Parinandi

Claudio M Lezama-Davila

Shalini Gautam

Matthew Gallovic

Kevin Peine

Robert Junkins

Ning Cheng

Fred Cope

Disclosed herein are methods of using immunomodulatory sterols as vaccine adjuvants. Accordingly, certain embodiments relates to pharmaceutical compositions containing at least one antigen and at least one immunomodulatory sterol; and, methods of inducing an immunomodulatory response in a patient by administering an immunomodulatory-effective amount of at least one immunomodulatory sterol.

Sterols as novel immunomodulatory agents and their use as vaccine adjuvants

The present invention provides a composition comprising a) a polyacetal polymer, a polyester polymer and/or a biodegradable polymer; b) a cyclic dinucleotide; and c) an antigen and/or an antibody, as well as methods of using same.

Methods and compositions for inducing an immune response

Compositions and methods of making a modified polyhydroxylated polymer comprising a polyhydroxylated polymer having reversibly modified hydroxyl groups, whereby the hydroxyl groups are modified by an acid-catalyzed reaction between a polydroxylated polymer and a reagent such as acetals, aldehydes, vinyl ethers and ketones such that the modified polyhydroxylated polymers become insoluble in water but freely soluble in common organic solvents allowing for the facile preparation of acid-sensitive materials. Materials made from these polymers can be made to degrade in a pH-dependent manner. Both hydrophobic and hydrophilic cargoes were successfully loaded into particles made from the present polymers using single and double emulsion techniques, respectively. Due to its ease of preparation, processability, pH-sensitivity, and biocompatibility, of the present modified polyhydroxylated polymers should find use in numerous drug delivery applications.

Acid-degradable and bioerodible modified polyhydroxylated materials

Provided are compounds and compositions for targeting macrophages and other CD206 high expressing cells.

Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis

In one aspect, the invention relates methods and compositions for treating parasitic diseases, for example, leishmaniasis. In a further aspect, the compounds of the methods and compositions are isolated from. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Antileishmanial compositions and methods of use

Compositions and methods for inhibiting Leishmaniasis using AIs are provided. Aspects provide compositions and methods for administering AIs alone or in combination with other compounds to infected hosts.

Compositions and methods for inhibiting leishmania

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Dublin, OH, United States of America

Eric M Bachelder