Lyten, Inc.

Eric Lewis Danielson

Sung Hyun Lim

Maurizio Tarsia

Gary Robert Larsen

A biological field-effect transistor (BioFET) includes source and drain regions formed in a substrate, an insulating layer disposed on a surface of the substrate, a gate disposed on the insulating layer and extending between the source and drain regions, a well region containing an electrolyte solution configured to retain an analyte, a three-dimensional (3D) graphene layer forming a channel region in the substrate, and a passivation layer. The graphene layer is biofunctionalized with a molecular recognition element configured to alter one or more electrical properties of the 3D graphene layer in response to exposure of the molecular recognition element to the analyte. The passivation layer is configured to prevent the electrolyte solution from contacting the source and drain. In some aspects, the 3D graphene layer is produced from carbon-containing inks. In other aspects, the 3D graphene layer includes a convoluted 3D structure configured to prevent graphene restacking.

Biofunctionalized three-dimensional (3D) graphene-based field-effect transistor (FET) sensor

A method for manufacturing a biological field-effect transistor (BioFET) is disclosed. In some implementations, the method may include preparing a carbonaceous dispersion by adding a three-dimensional (3D) graphene into a solvent; depositing the carbonaceous dispersion onto a p-type silicon wafer; spin-coating a positive photoresist over the carbonaceous dispersion; forming source and drain terminals on the p-type silicon wafer, the source and drain terminals in contact with the 3D graphene of the carbonaceous dispersion; removing residual photoresist from the carbonaceous dispersion by placing the p-type silicon wafer in 1-methyl-2-pyrrolidone (NMP); and biofunctionalizing the carbonaceous dispersion with a molecular recognition element configured to alter one or more electrical properties of the Bio-FET in response to exposure of the molecular recognition element to the analyte.

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Santa Clara, CA, United States of America

Eric Lewis Danielson